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Difference between revisions of "Lipoma"
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| Line 11: | Line 11: | ||
| IHC = S-100 +ve | | IHC = S-100 +ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = MDM2/CDK4 amplification absent | ||
| IF = | | IF = | ||
| Gross = soft yellow tissue - typically with a thin capsule and lobulated | | Gross = soft yellow tissue - typically with a thin capsule and lobulated | ||
| Line 43: | Line 43: | ||
Note: | Note: | ||
*May be quite large ~10 cm. | *May be quite large ~10 cm. | ||
*Thigh lesions are more likely to the malignant than other sites.<ref name=pmid27020493/> | |||
==Microscopic== | ==Microscopic== | ||
| Line 97: | Line 98: | ||
Image:Yellow_adipose_tissue_in_paraffin_section_-_lipids_washed_out.jpg | Mature fat. (WC) | Image:Yellow_adipose_tissue_in_paraffin_section_-_lipids_washed_out.jpg | Mature fat. (WC) | ||
</gallery> | </gallery> | ||
==Molecular== | |||
*MDM2/CDK4 gene amplification absent. | |||
**Testing suggested in: lesions greater than 10 cm.<ref name=pmid27020493>{{Cite journal | last1 = Wong | first1 = DD. | last2 = Low | first2 = IC. | last3 = Peverall | first3 = J. | last4 = Robbins | first4 = PD. | last5 = Spagnolo | first5 = DV. | last6 = Nairn | first6 = R. | last7 = Carey-Smith | first7 = RL. | last8 = Wood | first8 = D. | title = MDM2/CDK4 gene amplification in large/deep-seated 'lipomas': incidence, predictors and clinical significance. | journal = Pathology | volume = 48 | issue = 3 | pages = 203-9 | month = Apr | year = 2016 | doi = 10.1016/j.pathol.2016.02.007 | PMID = 27020493 }}</ref> | |||
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