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Difference between revisions of "Medical liver disease"
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→Images: added chf with Louis stage I
(→Autoimmune hepatitis-primary biliary cirrhosis overlap syndrome: Added an important overlap. A very difficult diagnostic problem is illustrated with features of both AIH & obstruction) |
(→Images: added chf with Louis stage I) |
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Centrilobular necrosis (seen in circulatory failure and with toxins/drugs). PAS without diastase shows ovoids of necrosis {UL 40X). Necrosis with central vein [yellow arrowhead], inflammatory cells, residual Councilman body [green arrowhead], and hepatocyte with mitotic figure [red arrowhead] (UR 400X). Trichrome highlights fibrosis about central vein [yellow arrowhead] & shows beginning scar formation [green arrowheads]. Note residual atrophic hepatocytes [blue arrowheads] (LL 400X). Portal triads are largely unaffected (LR 400X) | Centrilobular necrosis (seen in circulatory failure and with toxins/drugs). PAS without diastase shows ovoids of necrosis {UL 40X). Necrosis with central vein [yellow arrowhead], inflammatory cells, residual Councilman body [green arrowhead], and hepatocyte with mitotic figure [red arrowhead] (UR 400X). Trichrome highlights fibrosis about central vein [yellow arrowhead] & shows beginning scar formation [green arrowheads]. Note residual atrophic hepatocytes [blue arrowheads] (LL 400X). Portal triads are largely unaffected (LR 400X) | ||
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[[File:1 CHF 1 680x512px.tif|Dilated and undilated sinusoidal regions (40X).]] | |||
[[File:2 CHF 1 680x512px.tif|Thrombi in sinusoids; glycogenated nuclei likely reflect patient’s diabetes mellitus (400X).]] | |||
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[[File:3 CHF 1 680x512px.tif|Dilated portal vein (400X).]] | |||
[[File:4 CHF 1 680x512px.tif|Reticulin shows collapse (thick black lines) as well as a dilated portal vein (200X).]] | |||
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[[File:5 CHF 1 680x512px.tif|Trichrome shows space of Disse collagenization (pericellular fibrosis) (200X).]] | |||
[[File:6 CHF 1 680x512px.tif|Trichrome shows periportal fibrosis; no bridging was seen (200X).]] | |||
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Patient with congestive heart failure and stage I fibrosis. Dilated and undilated sinusoidal regions (left row 1 40X). Thrombi in sinusoids; glycogenated nuclei likely reflect patient’s diabetes mellitus (right row 1 400X). Dilated portal vein (left row 2 400X). Reticulin shows collapse (thick black lines) as well as a dilated portal vein (right row 2 200X). Trichrome shows space of Disse collagenization (pericellular fibrosis) (left row 3 200X). Trichrome shows periportal fibrosis; no bridging was seen (right row 3 200X). | |||
==Drug-induced liver disease== | ==Drug-induced liver disease== | ||