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Difference between revisions of "Chordoma"
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| LMDDx = [[chondrosarcoma]], [[myxoid lesions]], [[parachordoma]], chordoid lesions (e.g. chordoid glioma, [[chordoid meningioma]]), [[metastasis]] (e.g. [[clear cell renal cell carcinoma]]) | | LMDDx = [[chondrosarcoma]], [[myxoid lesions]], [[parachordoma]], chordoid lesions (e.g. chordoid glioma, [[chordoid meningioma]]), [[metastasis]] (e.g. [[clear cell renal cell carcinoma]]) | ||
| Stains = | | Stains = | ||
| IHC = S-100 +ve, AE1/AE3 +ve, Brachyury +ve, EMA +ve | | IHC = S-100 +ve, [[AE1/AE3]] +ve, Brachyury +ve, [[EMA]] +ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 105: | Line 105: | ||
Features:<ref>URL: [http://path.upmc.edu/cases/case312/micro.html http://path.upmc.edu/cases/case312/micro.html]. Accessed on: 14 January 2012.</ref><ref name=pmid2431128>{{Cite journal | last1 = Coindre | first1 = JM. | last2 = Rivel | first2 = J. | last3 = Trojani | first3 = M. | last4 = De Mascarel | first4 = I. | last5 = De Mascarel | first5 = A. | title = Immunohistological study in chordomas. | journal = J Pathol | volume = 150 | issue = 1 | pages = 61-3 | month = Sep | year = 1986 | doi = 10.1002/path.1711500110 | PMID = 2431128 }}</ref> | Features:<ref>URL: [http://path.upmc.edu/cases/case312/micro.html http://path.upmc.edu/cases/case312/micro.html]. Accessed on: 14 January 2012.</ref><ref name=pmid2431128>{{Cite journal | last1 = Coindre | first1 = JM. | last2 = Rivel | first2 = J. | last3 = Trojani | first3 = M. | last4 = De Mascarel | first4 = I. | last5 = De Mascarel | first5 = A. | title = Immunohistological study in chordomas. | journal = J Pathol | volume = 150 | issue = 1 | pages = 61-3 | month = Sep | year = 1986 | doi = 10.1002/path.1711500110 | PMID = 2431128 }}</ref> | ||
*S-100 +ve - '''important'''. | *S-100 +ve - '''important'''. | ||
*AE1/AE3 +ve - '''important'''. | *[[AE1/AE3]] +ve - '''important'''. | ||
*Brachyury +ve - '''key stain'''. | *Brachyury +ve - '''key stain'''. | ||
**Protein important for axial development, affects notochord development.<ref name=omim601397>{{OMIM|601397}}</ref> | **Protein important for axial development, affects notochord development.<ref name=omim601397>{{OMIM|601397}}</ref> | ||
**''Brachyury'' literally means ''short tail''.<ref>URL: [http://www.jstor.org/pss/86845 http://www.jstor.org/pss/86845]. Accessed on: 18 May 2010.</ref> | **''Brachyury'' literally means ''short tail''.<ref>URL: [http://www.jstor.org/pss/86845 http://www.jstor.org/pss/86845]. Accessed on: 18 May 2010.</ref> | ||
*EMA +ve. | *[[EMA]] +ve. | ||
*PAX8 -ve (1 +ve (weak) of 12.<ref name=pmid21102418>{{Cite journal | last1 = Sangoi | first1 = AR. | last2 = Karamchandani | first2 = J. | last3 = Lane | first3 = B. | last4 = Higgins | first4 = JP. | last5 = Rouse | first5 = RV. | last6 = Brooks | first6 = JD. | last7 = McKenney | first7 = JK. | title = Specificity of brachyury in the distinction of chordoma from clear cell renal cell carcinoma and germ cell tumors: a study of 305 cases. | journal = Mod Pathol | volume = 24 | issue = 3 | pages = 425-9 | month = Mar | year = 2011 | doi = 10.1038/modpathol.2010.196 | PMID = 21102418 }}</ref>). | *[[PAX8]] -ve (1 +ve (weak) of 12.<ref name=pmid21102418>{{Cite journal | last1 = Sangoi | first1 = AR. | last2 = Karamchandani | first2 = J. | last3 = Lane | first3 = B. | last4 = Higgins | first4 = JP. | last5 = Rouse | first5 = RV. | last6 = Brooks | first6 = JD. | last7 = McKenney | first7 = JK. | title = Specificity of brachyury in the distinction of chordoma from clear cell renal cell carcinoma and germ cell tumors: a study of 305 cases. | journal = Mod Pathol | volume = 24 | issue = 3 | pages = 425-9 | month = Mar | year = 2011 | doi = 10.1038/modpathol.2010.196 | PMID = 21102418 }}</ref>). | ||
*Other keratins:<ref name=pmid9195570>{{Cite journal | last1 = Naka | first1 = T. | last2 = Iwamoto | first2 = Y. | last3 = Shinohara | first3 = N. | last4 = Chuman | first4 = H. | last5 = Fukui | first5 = M. | last6 = Tsuneyoshi | first6 = M. | title = Cytokeratin subtyping in chordomas and the fetal notochord: an immunohistochemical analysis of aberrant expression. | journal = Mod Pathol | volume = 10 | issue = 6 | pages = 545-51 | month = Jun | year = 1997 | doi = | PMID = 9195570 }}</ref> | *Other keratins:<ref name=pmid9195570>{{Cite journal | last1 = Naka | first1 = T. | last2 = Iwamoto | first2 = Y. | last3 = Shinohara | first3 = N. | last4 = Chuman | first4 = H. | last5 = Fukui | first5 = M. | last6 = Tsuneyoshi | first6 = M. | title = Cytokeratin subtyping in chordomas and the fetal notochord: an immunohistochemical analysis of aberrant expression. | journal = Mod Pathol | volume = 10 | issue = 6 | pages = 545-51 | month = Jun | year = 1997 | doi = | PMID = 9195570 }}</ref> | ||
**CK8 +ve (16/16). | **CK8 +ve (16/16). | ||
**CK19 +ve (16/16). | **CK19 +ve (16/16). | ||
**CK18 +ve/-ve (9 +ve/16). | **CK18 +ve/-ve (9 +ve/16). | ||
**CK7 -ve (1 +ve/16). | **[[CK7]] -ve (1 +ve/16). | ||
**CK20 -ve (0 +ve/16). | **[[CK20]] -ve (0 +ve/16). | ||
Classic chordoma panel:<ref name=pmid24296480>{{Cite journal | last1 = Shen | first1 = J. | last2 = Shi | first2 = Q. | last3 = Lu | first3 = J. | last4 = Wang | first4 = DL. | last5 = Zou | first5 = TM. | last6 = Yang | first6 = HL. | last7 = Zhu | first7 = GQ. | title = Histological study of chordoma origin from fetal notochordal cell rests. | journal = Spine (Phila Pa 1976) | volume = 38 | issue = 25 | pages = 2165-70 | month = Dec | year = 2013 | doi = 10.1097/BRS.0000000000000010 | PMID = 24296480 }}</ref> | Classic chordoma panel:<ref name=pmid24296480>{{Cite journal | last1 = Shen | first1 = J. | last2 = Shi | first2 = Q. | last3 = Lu | first3 = J. | last4 = Wang | first4 = DL. | last5 = Zou | first5 = TM. | last6 = Yang | first6 = HL. | last7 = Zhu | first7 = GQ. | title = Histological study of chordoma origin from fetal notochordal cell rests. | journal = Spine (Phila Pa 1976) | volume = 38 | issue = 25 | pages = 2165-70 | month = Dec | year = 2013 | doi = 10.1097/BRS.0000000000000010 | PMID = 24296480 }}</ref> | ||