Difference between revisions of "Multiple endocrine neoplasia"

Multiple endocrine neoplasia (view source)

506 bytes added , 21:14, 19 March 2011

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 ==Details==
+===MEN 1===
+Characteristics:<ref name=Ref_PBoD8_1162>{{Ref PBoD8|1162}}}}</ref>
+*Endocrine tumours usu. lead to most of the morbidity.
+**Usu. arise in the duodenum.
+***Zollinger-Ellison syndrome is common.
 ===MEN 2A===
+Characteristics:<ref name=Ref_PBoD8_1162>{{Ref PBoD8|1162}}}}</ref>
+*Medullary [[thyroid]] carcinoma - in almost 100%.
 *Ganglioneuromatosis of the alimentary tract.<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/162300 http://www.ncbi.nlm.nih.gov/omim/162300]. Accessed on: 19 November 2010.</ref><ref name=pmid17306015>{{cite journal |author=Haraguchi M, Kinoshita H, Koori M, ''et al.'' |title=Multiple rectal carcinoids with diffuse ganglioneuromatosis |journal=World J Surg Oncol |volume=5 |issue= |pages=19 |year=2007 |pmid=17306015 |pmc=1805501 |doi=10.1186/1477-7819-5-19 |url=}}</ref>
 **Extra large nerves in GI tract.
@@ Line 25: / Line 33: @@
 Images:
 *[http://wjso.com/content/5/1/19/figure/F3 Ganglioneuromatosis - crappy quality (wjso.com)].
+Trivia:
+*In MEN 2A and 2B the ''RET'' gene is abnormally activated.  In [[Hirschsprung disease]], it is inactivated.<ref name=Ref_PBoD8_1162>{{Ref PBoD8|1162}}}}</ref>
 ===MEN 2B===
-*Has a [[Marfan syndrome|marfanoid]] habitus.<ref name=Ref_PBoD8_1160>{{Ref PBoD8|1160}}}}</ref>
+Characteristics:
+*[[Marfan syndrome|Marfanoid]] habitus.<ref name=Ref_PBoD8_1160>{{Ref PBoD8|1160}}}}</ref>
 ==References==