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*+/-Touton [[giant cell]] - '''key feature'''. | *+/-Touton [[giant cell]] - '''key feature'''. | ||
**Large multi-nucleated cells where nuclei are distributed at the cell periphery. | **Large multi-nucleated cells where nuclei are distributed at the cell periphery. | ||
Notes: | |||
*Must prove they are non-Langerhans cell histiocytes, esp. if no Touton giant cells. | |||
DDx: | DDx: | ||
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*[[Erdheim-Chester disease]] - usu. [[BRAF V600E mutated]].<ref name=pmid22879539>{{Cite journal | last1 = Haroche | first1 = J. | last2 = Charlotte | first2 = F. | last3 = Arnaud | first3 = L. | last4 = von Deimling | first4 = A. | last5 = Hélias-Rodzewicz | first5 = Z. | last6 = Hervier | first6 = B. | last7 = Cohen-Aubart | first7 = F. | last8 = Launay | first8 = D. | last9 = Lesot | first9 = A. | title = High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses. | journal = Blood | volume = 120 | issue = 13 | pages = 2700-3 | month = Sep | year = 2012 | doi = 10.1182/blood-2012-05-430140 | PMID = 22879539 }}</ref> | *[[Erdheim-Chester disease]] - usu. [[BRAF V600E mutated]].<ref name=pmid22879539>{{Cite journal | last1 = Haroche | first1 = J. | last2 = Charlotte | first2 = F. | last3 = Arnaud | first3 = L. | last4 = von Deimling | first4 = A. | last5 = Hélias-Rodzewicz | first5 = Z. | last6 = Hervier | first6 = B. | last7 = Cohen-Aubart | first7 = F. | last8 = Launay | first8 = D. | last9 = Lesot | first9 = A. | title = High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses. | journal = Blood | volume = 120 | issue = 13 | pages = 2700-3 | month = Sep | year = 2012 | doi = 10.1182/blood-2012-05-430140 | PMID = 22879539 }}</ref> | ||
*[[Rosai-Dorfman disease]] - Emperipolesis. | *[[Rosai-Dorfman disease]] - Emperipolesis. | ||
*[[Necrobiotic xanthogranuloma]] - also may have Touton giant cells. | |||
* | |||
===Images=== | ===Images=== | ||
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*[[Dermatopathology]]. | *[[Dermatopathology]]. | ||
*[[Pediatric pathology]]. | *[[Pediatric pathology]]. | ||
==References== | ==References== |
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