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===Microscopic=== | ===Microscopic=== | ||
Various criteria exist for this diagnosis. The most widely used is the ''Weiss criteria'', which is a big long clunker. | Various criteria exist for this diagnosis. The most widely used is the ''Weiss criteria'', which is a big long clunker. | ||
Image: | |||
*[http://commons.wikimedia.org/wiki/File:Adrnal_cortical_carcinoma.JPG ACC (AFIP/WC)]. | |||
Notes: | |||
*Tumour may contain fat.<ref name=pmid15688105>{{cite journal |author=Heye S, Woestenborghs H, Van Kerkhove F, Oyen R |title=Adrenocortical carcinoma with fat inclusion: case report |journal=Abdom Imaging |volume=30 |issue=5 |pages=641–3 |year=2005 |pmid=15688105 |doi=10.1007/s00261-004-0281-5 |url=}}</ref> | |||
====Adult==== | ====Adult==== | ||
=====Weiss criteria===== | =====Weiss criteria===== | ||
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=====Volante criteria===== | =====Volante criteria===== | ||
There is a simplified set of criteria by ''Volante et al.'' - that is not widely used:<ref name=pmid19912359>{{cite journal |author=Volante M, Bollito E, Sperone P, ''et al.'' |title=Clinicopathological study of a series of 92 adrenocortical carcinomas: from a proposal of simplified diagnostic algorithm to prognostic stratification |journal=Histopathology |volume=55 |issue=5 |pages=535–43 |year=2009 |month=November |pmid=19912359 |doi=10.1111/j.1365-2559.2009.03423.x |url=}}</ref> | There is a simplified set of criteria by ''Volante et al.'' - that is not widely used:<ref name=pmid19912359>{{cite journal |author=Volante M, Bollito E, Sperone P, ''et al.'' |title=Clinicopathological study of a series of 92 adrenocortical carcinomas: from a proposal of simplified diagnostic algorithm to prognostic stratification |journal=Histopathology |volume=55 |issue=5 |pages=535–43 |year=2009 |month=November |pmid=19912359 |doi=10.1111/j.1365-2559.2009.03423.x |url=}}</ref> | ||
*Reticular network disruption (with reticulin staining). | |||
*One of the three following: | |||
*#Abundant mitoses >5/50 high-power fields - definition suffers from [[HPFitis]]. | |||
*#Necrosis. | |||
*#Vascular invasion. | |||
====Pediatric==== | ====Pediatric==== |
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