Difference between revisions of "Steatohepatitis"

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Steatohepatitis (view source)

Revision as of 21:40, 16 June 2016

169 bytes removed ,  21:40, 16 June 2016
→‎Microscopic
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**If less than 10% ... consider alt. diagnosis/disease process.
**If less than 10% ... consider alt. diagnosis/disease process.
*Hepatocyte injury:
*Hepatocyte injury:
**[[Ballooning degeneration]] - '''key feature'''.<ref name=pmid11296695>{{Cite journal  | last1 = Brunt | first1 = EM. | title = Nonalcoholic steatohepatitis: definition and pathology. | journal = Semin Liver Dis | volume = 21 | issue = 1 | pages = 3-16 | month =  | year = 2001 | doi =  | PMID = 11296695 }}</ref>
**[[Ballooning degeneration]] - '''key feature'''. †
**Mallory bodies.
**Mallory bodies.
***Mallory body wannabes: "occasional cytoplasmic clumping".
***Mallory body wannabes: "occasional cytoplasmic clumping".
*+/-''Chicken-wire'' perisinusoidal fibrosis +/- zone III (centrilobular) fibrosis (early).
*+/-''Chicken-wire'' perisinusoidal fibrosis +/- zone III (centrilobular) fibrosis (early).
**Late-stage disease - portal bridging.<ref name=pmid14991537>{{Cite journal  | last1 = Gramlich | first1 = T. | last2 = Kleiner | first2 = DE. | last3 = McCullough | first3 = AJ. | last4 = Matteoni | first4 = CA. | last5 = Boparai | first5 = N. | last6 = Younossi | first6 = ZM. | title = Pathologic features associated with fibrosis in nonalcoholic fatty liver disease. | journal = Hum Pathol | volume = 35 | issue = 2 | pages = 196-9 | month = Feb | year = 2004 | doi =  | PMID = 14991537 }}</ref>
**Late-stage disease - portal bridging.<ref name=pmid14991537>{{Cite journal  | last1 = Gramlich | first1 = T. | last2 = Kleiner | first2 = DE. | last3 = McCullough | first3 = AJ. | last4 = Matteoni | first4 = CA. | last5 = Boparai | first5 = N. | last6 = Younossi | first6 = ZM. | title = Pathologic features associated with fibrosis in nonalcoholic fatty liver disease. | journal = Hum Pathol | volume = 35 | issue = 2 | pages = 196-9 | month = Feb | year = 2004 | doi =  | PMID = 14991537 }}</ref>
Note:
* † Brunt does ''not'' require ballooning to be present to call ''steatohepatitis'';<ref name=pmid10484010/> however, a table in a later paper Brunt paper (surveying pathologists) suggest that a significant number of pathologist may consider it as a required finding.<ref name=pmid11296695>{{Cite journal  | last1 = Brunt | first1 = EM. | title = Nonalcoholic steatohepatitis: definition and pathology. | journal = Semin Liver Dis | volume = 21 | issue = 1 | pages = 3-16 | month =  | year = 2001 | doi =  | PMID = 11296695 }}</ref>


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Note:
Note:
*‡ Brunt does ''not'' require ballooning to be present to call ''steatohepatitis''.<ref name=pmid10484010/> Brunt in a later paper (surveying pathologists) suggest that a significant number of pathologist see it as a diagnostic criterion.<ref name=pmid11296695>{{Cite journal  | last1 = Brunt | first1 = EM. | title = Nonalcoholic steatohepatitis: definition and pathology. | journal = Semin Liver Dis | volume = 21 | issue = 1 | pages = 3-16 | month =  | year = 2001 | doi =  | PMID = 11296695 }}</ref>
*‡ Ballooning may be absent.<ref name=pmid10484010/>  


====Images====
====Images====
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