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'''Stratified mucin-producing intraepithelial lesion of the cervix''' is a rare dysplastic lesion of the [[uterine cervix]]. | '''Stratified mucin-producing intraepithelial lesion of the cervix''' is a rare dysplastic lesion of the [[uterine cervix]]. It is considered to be an overlap of [[endocervical adenocarcinoma in situ]] and [[squamous intraepithelial lesion]].<ref name=pmid25039487/> | ||
It is abbreviated '''SMILE''' ('''S'''tratified '''M'''ucin-producing '''I'''ntraepithelial '''LE'''sion). | It is abbreviated '''SMILE''' ('''S'''tratified '''M'''ucin-producing '''I'''ntraepithelial '''LE'''sion). | ||
==General== | ==General== | ||
*Rare | *Rare ~0.6% of cervix lesions in one series.<ref name=pmid25039487>{{Cite journal | last1 = Boyle | first1 = DP. | last2 = McCluggage | first2 = WG. | title = Stratified mucin-producing intraepithelial lesion (SMILE): report of a case series with associated pathological findings. | journal = Histopathology | volume = 66 | issue = 5 | pages = 658-63 | month = Apr | year = 2015 | doi = 10.1111/his.12498 | PMID = 25039487 }}</ref> | ||
*Often accompanied by [[cervical intraepithelial neoplasia]] and [[adenocarcinoma in situ]].<ref name=pmid11023104/> | *Often accompanied by [[cervical intraepithelial neoplasia]] and [[adenocarcinoma in situ]].<ref name=pmid11023104/> | ||
Management: | |||
*Like [[endocervical AIS]].<ref name=pmid25039487/> | |||
==Microscopic== | ==Microscopic== | ||
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*[[HSIL]]. | *[[HSIL]]. | ||
**Mucin may be present superficially.<ref name=pmid11023104/> | **Mucin may be present superficially.<ref name=pmid11023104/> | ||
*[[Endocervical AIS]]. | |||
===Images=== | ===Images=== |
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