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'''Anaplastic astrocytoma''' (AKA: ''high-grade astrocytoma'') is a infiltrating neoplasm of the diffuse astrocytic and oligodendroglial tumor group occurring in the CNS white matter. | |||
* Most common grade III WHO glioma in adults (peaks between 40-50 years). | |||
* Approx 5% of all [[glioma]]s.<ref>{{Cite journal | last1 = Ohgaki | first1 = H. | last2 = Kleihues | first2 = P. | title = Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. | journal = J Neuropathol Exp Neurol | volume = 64 | issue = 6 | pages = 479-89 | month = Jun | year = 2005 | doi = | PMID = 15977639 }}</ref> | |||
* Usually shows progression to [[glioblastoma]] sooner or later. | |||
WHO 2016 categorization combines morphology and genetics into following groups:<ref>{{Cite journal | last1 = Louis | first1 = DN. | last2 = Perry | first2 = A. | last3 = Reifenberger | first3 = G. | last4 = von Deimling | first4 = A. | last5 = Figarella-Branger | first5 = D. | last6 = Cavenee | first6 = WK. | last7 = Ohgaki | first7 = H. | last8 = Wiestler | first8 = OD. | last9 = Kleihues | first9 = P. | title = The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. | journal = Acta Neuropathol | volume = 131 | issue = 6 | pages = 803-20 | month = Jun | year = 2016 | doi = 10.1007/s00401-016-1545-1 | PMID = 27157931 }}</ref> | |||
*Anaplastic astrocytoma, IDH-mutant (ICD-O: 9401/3). | |||
*Anaplastic astrocytoma, IDH-wildtype (ICD-O: 9400/3). | |||
*Anaplastic astrocytoma,NOS (ICD-O: 9400/3) - genetic data missing. | |||
==Radiology/Clinic== | |||
*Mass effect. | |||
*Seizures. | |||
*Neurologic decifit. | |||
*The majority are contrast-enhanching, T2 bright. | |||
==Macroscopy== | |||
*No clear demarcation from white matter. | |||
*Invaded structures may appear enlarged. | |||
*Softer consistency and opacity. | |||
*No necrosis. | |||
#redirect [[Neuropathology_tumours#Infiltrative_astrocytomas]] | #redirect [[Neuropathology_tumours#Infiltrative_astrocytomas]] | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Neuropathology tumours]] | [[Category:Neuropathology tumours]] | ||
[[Category:WHO grade III tumours]] | [[Category:WHO grade III tumours]] | ||