Difference between revisions of "Adrenal gland"

Adrenal gland (view source)

905 bytes added , 17:28, 15 March 2011

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 =Malignant neoplasms=
-==Adrenocortical carcinoma (ACC)==
+==Adrenocortical carcinoma==
-Epidemiology:
+*[[AKA]] ''adrenal cortical carcinoma''.
+*Abbreviated ''ACC''.
+===General===
 *Prognosis sucks.
+===Gross===
+*+/-Encapsulated.
+*Necrotic-appearing.
+Image:
+*[http://commons.wikimedia.org/wiki/File:Adrenal_cortical_carcinoma.JPG ACC - gross (WC)].
 ===Microscopic===
-Features:
+Diagnosis based on the presence of three of the following (known as ''Weiss criteria''):<ref name=pmid20551521>{{cite journal |author=Jain M, Kapoor S, Mishra A, Gupta S, Agarwal A |title=Weiss criteria in large adrenocortical tumors: a validation study |journal=Indian J Pathol Microbiol |volume=53 |issue=2 |pages=222–6 |year=2010 |pmid=20551521 |doi=10.4103/0377-4929.64325 |url=}}</ref>
-*Very pleomorphic nuclei.
+#High nuclear grade.
-*High mitotic rate.
+#High mitotic rate.
-*Atypical mitoses.
+#Atypical mitoses.
-*Eosinophilic cytoplasm.
+#Cleared cytoplasm in >= 25% of tumour cells.
+#Sheeting (diffuse architecture) in >= 1/3 of tumour cells.
+#Necrosis in nests.
+#Venous invasion.
+#Adrenal sinusoid invasion; lymphovascular space invasion within the adrenal gland.
+#Capsular invasion.
+Image:
+*[http://commons.wikimedia.org/wiki/File:Adrnal_cortical_carcinoma.JPG ACC (AFIP/WC)].
 ==Malignant pheochromoctyoma==