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→IHC: update
Jensflorian (talk | contribs) (→Neuronal and mixed neuronal/glial tumours: entity added) |
Jensflorian (talk | contribs) (→IHC: update) |
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*Ki-67 - usu. high >20% of cells. | *Ki-67 - usu. high >20% of cells. | ||
*p53 - often +ve. | *p53 - often +ve. | ||
* | *[[IDH-1]] (isocitrate dehydrogenase 1). | ||
**+ve in tumours that arose from low-grade gliomas.<ref name=pmid19228619>{{cite journal |author=Yan H, Parsons DW, Jin G, ''et al.'' |title=IDH1 and IDH2 mutations in gliomas |journal=N. Engl. J. Med. |volume=360 |issue=8 |pages=765–73 |year=2009 |month=February |pmid=19228619 |pmc=2820383 |doi=10.1056/NEJMoa0808710 |url=}}</ref> | **+ve in tumours that arose from low-grade gliomas.<ref name=pmid19228619>{{cite journal |author=Yan H, Parsons DW, Jin G, ''et al.'' |title=IDH1 and IDH2 mutations in gliomas |journal=N. Engl. J. Med. |volume=360 |issue=8 |pages=765–73 |year=2009 |month=February |pmid=19228619 |pmc=2820383 |doi=10.1056/NEJMoa0808710 |url=}}</ref> | ||
*** | *[[H3F3A|H3F3A K27M]] -ve | ||
**+ve cases to be classified as [[Astrocytoma#H3.3_K27M_mutated_glioma_of_the_midline|K27 mutated midline glioma]]. | |||
*[[ATRX]] -ve in tumors with low-grade precursor(most of them also IDH1/2 mutant). | |||
Notes: | Notes: | ||
*IDH1 and IDH2 mutations - better survival.<ref name=pmid20975057>{{cite journal |author=Houillier C, Wang X, Kaloshi G, ''et al.'' |title=IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas |journal=Neurology |volume=75 |issue=17 |pages=1560–6 |year=2010 |month=October |pmid=20975057 |doi=10.1212/WNL.0b013e3181f96282 |url=}}</ref> | *IDH1 and IDH2 mutations - better survival.<ref name=pmid20975057>{{cite journal |author=Houillier C, Wang X, Kaloshi G, ''et al.'' |title=IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas |journal=Neurology |volume=75 |issue=17 |pages=1560–6 |year=2010 |month=October |pmid=20975057 |doi=10.1212/WNL.0b013e3181f96282 |url=}}</ref> | ||
===Molecular=== | |||
See also: [[Molecular_pathology_tests#Neuropathology|Molecular Neuropathology]] | |||
==Astrocytic tumours== | ==Astrocytic tumours== | ||