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Difference between revisions of "Malignant peripheral nerve sheath tumour"
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Malignant peripheral nerve sheath tumour (view source)
Revision as of 10:17, 9 May 2016
, 10:17, 9 May 2016→Microscopic: update
Jensflorian (talk | contribs) (→General: update) |
Jensflorian (talk | contribs) (→Microscopic: update) |
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*Mitoses. | *Mitoses. | ||
*+/-Herring bone pattern. | *+/-Herring bone pattern. | ||
*Perivascular hypercellularity | *Perivascular hypercellularity. | ||
*Tumor herniation into vascular lumens | *Tumor herniation into vascular lumens. | ||
*"Pseudocapsule" with tumour invasion of adjacent tissue. | |||
Notes: | Notes: | ||
| Line 62: | Line 63: | ||
*Plexiform schwannoma. | *Plexiform schwannoma. | ||
*[[Malignant triton tumour]]. | *[[Malignant triton tumour]]. | ||
**aka. MPNST with mesenchymal differentiation. | |||
DDx of herring bone: | DDx of herring bone: | ||
| Line 80: | Line 82: | ||
===Grading=== | ===Grading=== | ||
*Can be graded histologically,<ref name=pmid14508395>{{cite journal |author=Zhou H, Coffin CM, Perkins SL, Tripp SR, Liew M, Viskochil DH |title=Malignant peripheral nerve sheath tumor: a comparison of grade, immunophenotype, and cell cycle/growth activation marker expression in sporadic and neurofibromatosis 1-related lesions |journal=Am. J. Surg. Pathol. |volume=27 |issue=10 |pages=1337–45 |year=2003 |month=October |pmid=14508395 |doi= |url=}}</ref> and this is prognostic.<ref name=pmid16923196>{{cite journal |author=Kar M, Deo SV, Shukla NK, ''et al.'' |title=Malignant peripheral nerve sheath tumors (MPNST)--clinicopathological study and treatment outcome of twenty-four cases |journal=World J Surg Oncol |volume=4 |issue= |pages=55 |year=2006 |pmid=16923196 |pmc=1560134 |doi=10.1186/1477-7819-4-55 |url=}}</ref> | *Can be graded histologically, according WHO<ref name=pmid14508395>{{cite journal |author=Zhou H, Coffin CM, Perkins SL, Tripp SR, Liew M, Viskochil DH |title=Malignant peripheral nerve sheath tumor: a comparison of grade, immunophenotype, and cell cycle/growth activation marker expression in sporadic and neurofibromatosis 1-related lesions |journal=Am. J. Surg. Pathol. |volume=27 |issue=10 |pages=1337–45 |year=2003 |month=October |pmid=14508395 |doi= |url=}}</ref> and this is prognostic.<ref name=pmid16923196>{{cite journal |author=Kar M, Deo SV, Shukla NK, ''et al.'' |title=Malignant peripheral nerve sheath tumors (MPNST)--clinicopathological study and treatment outcome of twenty-four cases |journal=World J Surg Oncol |volume=4 |issue= |pages=55 |year=2006 |pmid=16923196 |pmc=1560134 |doi=10.1186/1477-7819-4-55 |url=}}</ref> | ||
*grade IV: Presence of necrosis (3/4 of all MPNST). | |||
*grade III: Mitotic count exceeds 4/1 HPF. | |||
*grade II: nuclear size (<3x of neurofibroma cell), hyperchromatic nuclei. | |||
**overlap with cellular ("atypical") neurofibroma (DDx). | |||
Sarcoma grading system<ref name=pmid6693192>{{cite journal |author=Trojani M, Contesso G, Coindre JM, ''et al.'' |title=Soft-tissue sarcomas of adults; study of pathological prognostic variables and definition of a histopathological grading system |journal=Int. J. Cancer |volume=33 |issue=1 |pages=37–42 |year=1984 |month=January |pmid=6693192 |doi= |url=}}</ref> - based on: | Sarcoma grading system<ref name=pmid6693192>{{cite journal |author=Trojani M, Contesso G, Coindre JM, ''et al.'' |title=Soft-tissue sarcomas of adults; study of pathological prognostic variables and definition of a histopathological grading system |journal=Int. J. Cancer |volume=33 |issue=1 |pages=37–42 |year=1984 |month=January |pmid=6693192 |doi= |url=}}</ref> - based on: | ||