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Difference between revisions of "Talk:Heart transplant pathology"
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Talk:Heart transplant pathology (view source)
Revision as of 20:58, 9 March 2011
, 20:58, 9 March 2011→Biopsy - moderate: new section
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:ii) endomyocardial fibrosis, focal <br> | :ii) endomyocardial fibrosis, focal <br> | ||
:iii) endocardial lymphocytic infiltrate (Quilty effect), small | :iii) endocardial lymphocytic infiltrate (Quilty effect), small | ||
== Biopsy - moderate == | |||
===Microscopic description=== | |||
Multiple serial sections show that there is one large, and two smaller regions of perivascular, deep myocardial, lymphocyte-predominant inflammation. The large lesion is associated with, reactive endothelium, edema of the myocardium, cytoplasmic myocyte eosinophilia and moderate reactive nuclear enlargement. The myocardial vessels distant from the lymphocytic infiltrates, focally, show lymphocyte-margination without endothelial changes and without significant edema. | |||
The biopsy sample is adequate to pathologically evaluate acute cellular rejection activity. There is no significant endomyocardial fibrosis. Several lymphocytic infiltrates are seen superficially (Quilty effect). | |||
===Final diagnosis=== | |||
Heart allograft, endomyocardial biopsies x 4 - ISHLT Grade 1-2, mild-to-moderate acute cellular rejection, with: | |||
<br> i) antibody-mediated rejection (AMR) - 0 (by ordinary light microscopy) | |||
<br> ii) no significant endomyocardial fibrosis | |||
<br> iii) Quilty effect (endocardial lymphocytic infiltrate), several | |||