Account-creators
1,040
edits
Difference between revisions of "Epilepsy"
Jump to navigation
Jump to search
→Types: granule cell dispersion
Jensflorian (talk | contribs) (→Microscopic: Hippocampal sclerosis) |
Jensflorian (talk | contribs) (→Types: granule cell dispersion) |
||
| Line 20: | Line 20: | ||
*Mesial temporal sclerosis = scarring of the medial temporal lobe. | *Mesial temporal sclerosis = scarring of the medial temporal lobe. | ||
**Involves: hippocampus, parahippocampal gyrus and amygdala. | **Involves: hippocampus, parahippocampal gyrus and amygdala. | ||
*Granule cell dispersion | |||
===Hippocampal sclerosis=== | ===Hippocampal sclerosis=== | ||
| Line 33: | Line 34: | ||
Notes: | Notes: | ||
*Gliosis withot neuronal loss is not considered hippocampal sclerosis. | *Gliosis withot neuronal loss is not considered hippocampal sclerosis. | ||
===Granule cell dispersion=== | |||
*Affects dentate gyrus. | |||
*Observed in up to 40% specimen with hippocampal sclerosis. | |||
*Clinico-pathological classification:<ref>{{Cite journal | last1 = Blümcke | first1 = I. | last2 = Kistner | first2 = I. | last3 = Clusmann | first3 = H. | last4 = Schramm | first4 = J. | last5 = Becker | first5 = AJ. | last6 = Elger | first6 = CE. | last7 = Bien | first7 = CG. | last8 = Merschhemke | first8 = M. | last9 = Meencke | first9 = HJ. | title = Towards a clinico-pathological classification of granule cell dispersion in human mesial temporal lobe epilepsies. | journal = Acta Neuropathol | volume = 117 | issue = 5 | pages = 535-44 | month = May | year = 2009 | doi = 10.1007/s00401-009-0512-5 | PMID = 19277686 }}</ref> | |||
**Granule cell pathology (GCP) Type 1: Substantial granule cell loss. | |||
**Granule cell pathology (GCP) Type 2: Cell dispersion, ectopic neurons or clusters of neurons in the molecular layer or bi-lamination. | |||
Clinic: | |||
*Association with longer epilepsy duration. | |||
DDx: | DDx: | ||