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Difference between revisions of "Breast calcifications"
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(Created page with "'''Breast calcifications''' may be found in benign or malignant breast specimens. ==General== *Radiologists can pick-up calcifications that are approximately 100 micrometers...") |
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'''Breast calcifications''' may be found in benign or malignant breast specimens. | '''Breast calcifications''' may be found in benign or [[breast cancer|malignant breast]] specimens. | ||
==General== | ==General== | ||
*Abnormal breast calcifications are considered a marker of [[malignancy]]. | |||
*Radiologists can pick-up calcifications that are approximately 100 micrometers; if "calcs" is on the requisition one needs to find calcs this size.<ref>MUA. 1 October 2010.</ref> | *Radiologists can pick-up calcifications that are approximately 100 micrometers; if "calcs" is on the requisition one needs to find calcs this size.<ref>MUA. 1 October 2010.</ref> | ||
**The large calcs seen on radiology are approximately 1/5 - 1/6 the size of a HPF, if the field of view (FOV) is ~0.55 mm (as is the case with 22 mm-10x eye pieces and a 40x objective). | **The large calcs seen on radiology are approximately 1/5 - 1/6 the size of a HPF, if the field of view (FOV) is ~0.55 mm (as is the case with 22 mm-10x eye pieces and a 40x objective). | ||
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==Microscopic== | ==Microscopic== | ||
Features of calcification: | Features of calcification: | ||
*Purple globs (with concentric rings) on H&E - represent calcium phosphate. | *Purple globs (with concentric rings) on [[H&E stain|H&E]] - represent calcium phosphate. | ||
**Q. How to remember? A. '''P'''urple = '''P'''hosphate. | **Q. How to remember? A. '''P'''urple = '''P'''hosphate. | ||
*Often in the lumen of a gland, may be in the stroma. | *Often in the lumen of a gland, may be in the stroma. | ||
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Note: | Note: | ||
*Calcium oxalate visible with (light) polarization | *Calcium oxalate is not associated with malignancy<ref name=pmid26769216>{{Cite journal | last1 = Sharma | first1 = T. | last2 = Radosevich | first2 = JA. | last3 = Pachori | first3 = G. | last4 = Mandal | first4 = CC. | title = A Molecular View of Pathological Microcalcification in Breast Cancer. | journal = J Mammary Gland Biol Neoplasia | volume = | issue = | pages = | month = Jan | year = 2016 | doi = 10.1007/s10911-015-9349-9 | PMID = 26769216 }}</ref> - visible with (light) polarization. | ||
==See also== | ==See also== | ||