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Difference between revisions of "Clear cell renal cell carcinoma"
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Clear cell renal cell carcinoma (view source)
Revision as of 21:51, 29 February 2016
, 21:51, 29 February 2016no edit summary
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| Caption = Clear cell renal cell carcinoma. [[H&E stain]]. | | Caption = Clear cell renal cell carcinoma. [[H&E stain]]. | ||
| Synonyms = conventional renal cell carcinoma | | Synonyms = conventional renal cell carcinoma | ||
| Micro = solid or [[trabecular]] pattern, polygonal cells usually with clear cytoplasm, central nucleus, delicate branching vasculature (chicken wire-like), +/-hyaline bodies | | Micro = solid or [[trabecular]] pattern, polygonal cells usually with clear cytoplasm (may be eosinophilic - esp. in high grade tumours), central nucleus, delicate branching vasculature (chicken wire-like), +/-hyaline bodies | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[chromophobe renal cell carcinoma]], [[clear cell papillary renal cell carcinoma]], [[Xp11.2 translocation carcinoma]], [[adrenocortical carcinoma]], [[alveolar soft part sarcoma]] | | LMDDx = [[chromophobe renal cell carcinoma]], [[clear cell papillary renal cell carcinoma]], [[Xp11.2 translocation carcinoma]], [[adrenocortical carcinoma]], [[alveolar soft part sarcoma]] | ||
| Stains = [[Hale's colloidal iron stain]] -ve | | Stains = [[Hale's colloidal iron stain]] -ve | ||
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Features:<ref name=Ref_PBoD1017-8>{{Ref PBoD|1017-8}}</ref> | Features:<ref name=Ref_PBoD1017-8>{{Ref PBoD|1017-8}}</ref> | ||
*Clear cytoplasm. | *Clear cytoplasm. | ||
**May have eosinophilic cytoplasm (in high-grade tumours) - usually focal. | |||
*Delicate branching vasculature - '''key feature'''. | *Delicate branching vasculature - '''key feature'''. | ||
**Often called "chicken wire-like" vasculature. | **Often called "chicken wire-like" vasculature. | ||
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*+/-Rhabdoid cells: | *+/-Rhabdoid cells: | ||
**Eccentric nucleus. | **Eccentric nucleus. | ||
**Abundant eosinophilic | **Abundant eosinophilic cytoplasm. | ||
Notes: | Notes: | ||