Difference between revisions of "Neuropathology tumours"

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Neuropathology tumours (view source)

Revision as of 18:04, 2 March 2011

278 bytes added ,  18:04, 2 March 2011
→‎Infiltrative astrocytomas: more
(→‎Grading: re-order)
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===Overview===
===Overview===
*Pilocytic astrocytomas (WHO Grade I).
*Dysembryoplastic neuroepithelial tumour (DNT), (WHO Grade I).
*Low-grade (diffuse) astrocytomas (Grade II).
*Low-grade (diffuse) astrocytomas (Grade II).
*Anaplastic astrocytomas (Grade III).
*Anaplastic astrocytomas (Grade III).
*Glioblastoma (Grade IV).
*Glioblastoma (Grade IV).
Notes:
*Non-infiltrative gliomas:
**Pilocytic astrocytomas (WHO Grade I).
**Dysembryoplastic neuroepithelial tumour (DNT), (WHO Grade I).


===Microscopic===
===Microscopic===
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*Glial processes - '''key feature'''.
*Glial processes - '''key feature'''.
**Thin stringy cytoplasmic processes - best seen at high power in less cellular areas.
**Thin stringy cytoplasmic processes - best seen at high power in less cellular areas.
*No Rosenthal fibres within the tumour itself.


Images:
Images:
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**Glial: "blends into brain"/gradual transition to non-tumour brain.
**Glial: "blends into brain"/gradual transition to non-tumour brain.
**Non-glial: no glial processes.
**Non-glial: no glial processes.
 
*Rosenthal fibres within the tumour... make it into a [[pilocytic astrocytoma]].
====Table of common gliomas====
**Rosenthal fibres may be seen around a (very) slow growing tumour and represent a reactive process.
Histomorphologic comparison of common gliomas:
{| class="wikitable"
|'''Entity''' || '''Rosenthal <br>fibres / EGBs''' ||'''Nuclear atypia''' ||'''Mitoses''' || '''Necrosis or MVP''' || '''Infiltrative''' || '''Image'''
|-
|Pilocytic astrocytoma || yes || usu. no || usu. no || usu. no || no || [http://commons.wikimedia.org/wiki/File:Rosenthal_HE_40x.jpg]
|-
|Low-grade astrocytoma || no || yes || no || no || yes || image?
|-
|Anaplastic astrocytoma || no || yes || yes || no || yes || [http://commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_high_mag.jpg]
|-
|Glioblastoma || no || yes || yes || yes || yes || [http://commons.wikimedia.org/wiki/File:Glioblastoma_-_high_mag.jpg]
|}
Notes:
*''MVP'' = microvascular proliferation.
*''EGBs'' = eosinophilic granular bodies.


====Grading====
====Grading====
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**[http://commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_very_high_mag_-_cropped.jpg Anaplastic astrocytoma - very high mag. (WC)].
**[http://commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_very_high_mag_-_cropped.jpg Anaplastic astrocytoma - very high mag. (WC)].
**[http://commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_gfap_-_very_high_mag.jpg Anaplastic astrocytoma - GFAP - very high mag. (WC)].
**[http://commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_gfap_-_very_high_mag.jpg Anaplastic astrocytoma - GFAP - very high mag. (WC)].
=====Table of common gliomas - grading=====
Histomorphologic comparison of common gliomas:
{| class="wikitable"
|'''Entity''' || '''Rosenthal <br>fibres / EGBs''' ||'''Nuclear atypia''' ||'''Mitoses''' || '''Necrosis or MVP''' || '''Infiltrative''' || '''Image'''
|-
|Pilocytic astrocytoma || yes || usu. no || usu. no || usu. no || no || [http://commons.wikimedia.org/wiki/File:Rosenthal_HE_40x.jpg]
|-
|Low-grade astrocytoma || no || yes || no || no || yes || image?
|-
|Anaplastic astrocytoma || no || yes || yes || no || yes || [http://commons.wikimedia.org/wiki/File:Anaplastic_astrocytoma_-_high_mag.jpg]
|-
|Glioblastoma || no || yes || yes || yes || yes || [http://commons.wikimedia.org/wiki/File:Glioblastoma_-_high_mag.jpg]
|}
Notes:
*''MVP'' = microvascular proliferation.
*''EGBs'' = eosinophilic granular bodies.


===IHC===
===IHC===
Michael
48,836

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