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Prostate cancer grading (view source)
Revision as of 21:31, 22 January 2016
, 21:31, 22 January 2016→Grade groupings
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==Grade groupings== | ==Grade groupings== | ||
*[[AKA]] ''prognostic Gleason grade groupings''. | *[[AKA]] ''prognostic Gleason grade groupings''. | ||
*[[AKA]] ''a contemporary prostate cancer grading system''. | *[[AKA]] ''a contemporary prostate cancer grading system'', abbreviated ''CPCGS''. | ||
===Gleason score & CPCGS=== | |||
Proposed new system and old (modified) Gleason score:<ref name=jhu2014>URL: [http://urology.jhu.edu/newsletter/2014/prostate_cancer_2014_19.php http://urology.jhu.edu/newsletter/2014/prostate_cancer_2014_19.php]. Accessed on: 28 March 2015.</ref><ref name=pmid26166626>{{Cite journal | last1 = Epstein | first1 = JI. | last2 = Zelefsky | first2 = MJ. | last3 = Sjoberg | first3 = DD. | last4 = Nelson | first4 = JB. | last5 = Egevad | first5 = L. | last6 = Magi-Galluzzi | first6 = C. | last7 = Vickers | first7 = AJ. | last8 = Parwani | first8 = AV. | last9 = Reuter | first9 = VE. | title = A Contemporary Prostate Cancer Grading System: A Validated Alternative to the Gleason Score. | journal = Eur Urol | volume = | issue = | pages = | month = Jul | year = 2015 | doi = 10.1016/j.eururo.2015.06.046 | PMID = 26166626 }}</ref> | Proposed new system and old (modified) Gleason score:<ref name=jhu2014>URL: [http://urology.jhu.edu/newsletter/2014/prostate_cancer_2014_19.php http://urology.jhu.edu/newsletter/2014/prostate_cancer_2014_19.php]. Accessed on: 28 March 2015.</ref><ref name=pmid26166626>{{Cite journal | last1 = Epstein | first1 = JI. | last2 = Zelefsky | first2 = MJ. | last3 = Sjoberg | first3 = DD. | last4 = Nelson | first4 = JB. | last5 = Egevad | first5 = L. | last6 = Magi-Galluzzi | first6 = C. | last7 = Vickers | first7 = AJ. | last8 = Parwani | first8 = AV. | last9 = Reuter | first9 = VE. | title = A Contemporary Prostate Cancer Grading System: A Validated Alternative to the Gleason Score. | journal = Eur Urol | volume = | issue = | pages = | month = Jul | year = 2015 | doi = 10.1016/j.eururo.2015.06.046 | PMID = 26166626 }}</ref> | ||
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto" | {| class="wikitable sortable" style="text-align:center;margin-left:auto;margin-right:auto" | ||
! Prognostic group | ! Prognostic group (CPCGS) | ||
! Gleason score | ! Gleason score | ||
|- | |- | ||
| I | | I | ||
| 3+3 | | 6 (3+3) | ||
|- | |- | ||
| II | | II | ||
| Line 229: | Line 230: | ||
Rationale: | Rationale: | ||
*Patients won't be told they have a 6 out of 10 cancer, and then think it is an intermediate grade cancer that is worrisome. Instead, they will be told they have a 1 out of 5 cancer.<ref name=jhu2014>URL: [http://urology.jhu.edu/newsletter/2014/prostate_cancer_2014_19.php http://urology.jhu.edu/newsletter/2014/prostate_cancer_2014_19.php]. Accessed on: 28 March 2015.</ref> | *Patients won't be told they have a 6 out of 10 cancer, and then think it is an intermediate grade cancer that is worrisome. Instead, they will be told they have a 1 out of 5 cancer.<ref name=jhu2014>URL: [http://urology.jhu.edu/newsletter/2014/prostate_cancer_2014_19.php http://urology.jhu.edu/newsletter/2014/prostate_cancer_2014_19.php]. Accessed on: 28 March 2015.</ref> | ||
===Prognostication=== | |||
Recurrence free progression stratified by CPCGS:<ref name=pmid26166626/> | |||
{| class="wikitable sortable" style="text-align:center;margin-left:auto;margin-right:auto" | |||
! Prognostic group (CPCGS) | |||
! Hazard ratio<br>compared to Group I | |||
|- | |||
| I | |||
| (1.0) | |||
|- | |||
| II | |||
| 1.9 | |||
|- | |||
| III | |||
| 5.1 | |||
|- | |||
| IV | |||
| 8.0 | |||
|- | |||
| V | |||
| 11.7 | |||
|} | |||
==See also== | ==See also== | ||