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Difference between revisions of "Duodenum"
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→Weird stuff: deficiencies
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=Weird stuff= | =Weird stuff= | ||
==Disaccharidases deficiency== | |||
===General=== | |||
*Common among asians. | |||
*Includes: lactase, sucrase, and maltase. | |||
**Lactase changes seen with mild histomorphologic changes.<ref name=pmid2116456>{{cite journal |author=Langman JM, Rowland R |title=Activity of duodenal disaccharidases in relation to normal and abnormal mucosal morphology |journal=J. Clin. Pathol. |volume=43 |issue=7 |pages=537–40 |year=1990 |month=July |pmid=2116456 |pmc=502575 |doi= |url=}}</ref> | |||
**Maltase and sucrase only affected in moderate and severe lesions. | |||
===Microscopic=== | |||
Features:<ref name=pmid2116456>{{cite journal |author=Langman JM, Rowland R |title=Activity of duodenal disaccharidases in relation to normal and abnormal mucosal morphology |journal=J. Clin. Pathol. |volume=43 |issue=7 |pages=537–40 |year=1990 |month=July |pmid=2116456 |pmc=502575 |doi= |url=}}</ref> | |||
*Decreased villous-crypt ratio (mild to severe). | |||
*+/-Inflammation (only in moderate and severe). | |||
DDx: | |||
*Celiac disease.<ref name=pmid11252408>{{cite journal |author=Murray IA, Smith JA, Coupland K, Ansell ID, Long RG |title=Intestinal disaccharidase deficiency without villous atrophy may represent early celiac disease |journal=Scand. J. Gastroenterol. |volume=36 |issue=2 |pages=163–8 |year=2001 |month=February |pmid=11252408 |doi= |url=}}</ref> | |||
Notes: | |||
*May have normal histomorphology.<ref name=pmid2116456>{{cite journal |author=Langman JM, Rowland R |title=Activity of duodenal disaccharidases in relation to normal and abnormal mucosal morphology |journal=J. Clin. Pathol. |volume=43 |issue=7 |pages=537–40 |year=1990 |month=July |pmid=2116456 |pmc=502575 |doi= |url=}}</ref> | |||
==Whipple's disease== | ==Whipple's disease== | ||
===General=== | ===General=== | ||