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Difference between revisions of "Medullary thyroid carcinoma"
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Medullary thyroid carcinoma (view source)
Revision as of 05:42, 2 January 2016
, 05:42, 2 January 2016no edit summary
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| LMDDx = | | LMDDx = | ||
| Stains = congo red +ve (amyloid deposits) | | Stains = congo red +ve (amyloid deposits) | ||
| IHC = calcitonin +ve, CEA +ve, chromogranin A +ve, synaptophysin +ve, thyroglobulin -ve (usually) | | IHC = calcitonin +ve, [[CEA]] +ve, chromogranin A +ve, synaptophysin +ve, thyroglobulin -ve (usually) | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 105: | Line 105: | ||
DDx: | DDx: | ||
*Other thyroid | *Other thyroid tumours: | ||
**[[Anaplastic thyroid carcinoma]]. | **[[Anaplastic thyroid carcinoma]]. | ||
**[[Papillary thyroid carcinoma]]. | **[[Papillary thyroid carcinoma]]. | ||
**[[Hurthle cell carcinoma]] | **[[Hurthle cell carcinoma]] | ||
***The oncocytic variant of medullary carcinoma can be confused with Hurthle cell carcinoma. Clues to suggest medullary carcinoma: | ***The oncocytic variant of medullary carcinoma can be confused with [[Hurthle cell carcinoma]]. Clues to suggest medullary carcinoma: | ||
****Cytoplasm is amphophilic as opposed to eosinophilic | ****Cytoplasm is amphophilic as opposed to eosinophilic | ||
****Nests of tumour cells separated by fibrous septa | ****Nests of tumour cells separated by fibrous septa | ||
*[[C-cell hyperplasia]]. | |||
**Invasive medullary carcinoma shows fibrosis around tumor cells and stains more weakly for calcitonin. | |||
*Other neuroendocrine tumours - primary or metastatic: | |||
*Other neuroendocrine | **[[Paraganglioma]] - negative for keratin, calcitonin and [[CEA]]. | ||
**[[Paraganglioma]] - | **[[Carcinoid]] - negative for calcitonin. | ||
**[[Carcinoid]] - | *Metastatic [[melanoma]]. | ||
**Pigment. | |||
**Melanoma markers positive, calcitonin and CEA negative. | |||
===Images=== | ===Images=== | ||