Difference between revisions of "Pulmonary Langerhans cell histiocytosis"

Pulmonary Langerhans cell histiocytosis (view source)

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-#redirect [[Medical_lung_diseases#Pulmonary_Langerhans_cell_histiocytosis]]
+'''Pulmonary Langerhans cell histiocytosis''' is an uncommon [[smoking|smoking-related lung disease]].
+It is also known as '''eosinophilic granuloma of the lung'''.
+==General==
+*Associated with smoking.<ref name=Ref_PPP234>{{Ref PPP|234}}</ref>
+*Not associated with systemic diseases of Langerhans cells ([[AKA]] [[Langerhans cell histiocytosis|Hand-Schueller-Christian disease]]).
+Subtypes:<ref name=Ref_PPP234/>
+*Cellular form.
+*Fibrotic form.
+One form usually predominates.
+===Radiology==
+*Upper lung zones.
+==Microscopic==
+Features:<ref name=Ref_PPP237>{{Ref PPP|237}}</ref>
+*Cellular peribronchiolar nodules with:
+**Langerhans cells - '''key feature''':
+***Pale staining nucleus (H&E) with nuclear infolding - "crumpled tissue paper" appearance.
+**+/-Smoker's macrophages (brown pigmented airspace macrophages).
+**+/-Eosinophilia (may be rare) - '''significantly narrow DDx'''.
+**Chronic inflammatory cells (lymphocytes). (???)
+Images:
+*[http://path.upmc.edu/cases/case299.html Pulmonary LCH & adenocarcinoma - several images (upmc.edu)].
+==IHC==
+*Langerhans cells: S100+ and CD1a+.<ref name=Ref_PPP237>{{Ref PPP|237}}</ref>
+==See also==
+*[[Medical lung diseases]].
+==References==
+{{Reflist|2}}
 [[Category:Diagnosis]]
+[[Category:Medical lung diseases]]