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Peripheral nerve sheath tumours (view source)
Revision as of 08:01, 14 December 2015
, 08:01, 14 December 2015→Palisaded encapsulated neuroma: +pictures
Jensflorian (talk | contribs) (→Perineurioma: pic + facts) |
Jensflorian (talk | contribs) (→Palisaded encapsulated neuroma: +pictures) |
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*Abbreviated ''PEN''. | *Abbreviated ''PEN''. | ||
*[[AKA]] ''palisaded and encapsulated neuroma''. | *[[AKA]] ''palisaded and encapsulated neuroma''. | ||
*[[AKA]] ''solitary circumscribed neuroma''. | |||
===General=== | ===General=== | ||
*Flesh-colour [[papule]] - classically on the face.<ref name=Ref_Derm536>{{Ref Derm|536}}</ref> | *Flesh-colour [[papule]] - classically on the face.<ref name=Ref_Derm536>{{Ref Derm|536}}</ref> | ||
*Isolated finding - not associated with a systemic disease or malignancy.<ref name=pmid18718196>{{Cite journal | last1 = Newman | first1 = MD. | last2 = Milgraum | first2 = S. | title = Palisaded encapsulated neuroma (PEN): an often misdiagnosed neural tumor. | journal = Dermatol Online J | volume = 14 | issue = 7 | pages = 12 | month = | year = 2008 | doi = | PMID = 18718196 }}</ref> | *Isolated finding - not associated with a systemic disease or malignancy.<ref name=pmid18718196>{{Cite journal | last1 = Newman | first1 = MD. | last2 = Milgraum | first2 = S. | title = Palisaded encapsulated neuroma (PEN): an often misdiagnosed neural tumor. | journal = Dermatol Online J | volume = 14 | issue = 7 | pages = 12 | month = | year = 2008 | doi = | PMID = 18718196 }}</ref> | ||
*Superficial skin.<ref>S. Sade. 8 September 2011.</ref> | *Superficial skin papule.<ref>S. Sade. 8 September 2011.</ref> | ||
*It is considered hyperplastic rather than neoplastic. <ref>Rosai & Ackermann, Surgical Pathology, 10th ed. p183</ref> | |||
===Microscopic=== | ===Microscopic=== | ||
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**#Not vacuolated. | **#Not vacuolated. | ||
**#Nuclei have pointy ends. | **#Nuclei have pointy ends. | ||
**#Sometimes epitheloid appearance. | |||
*Intralesional clefts. | *Intralesional clefts. | ||
**Useful to differentiate from schwannoma. | **Useful to differentiate from schwannoma. | ||
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Images: | Images: | ||
*[http://dermatology.cdlib.org/147/case_presentation/pen/2.jpg PEN (cdlib.org)].<ref name=pmid18718196>{{Cite journal | last1 = Newman | first1 = MD. | last2 = Milgraum | first2 = S. | title = Palisaded encapsulated neuroma (PEN): an often misdiagnosed neural tumor. | journal = Dermatol Online J | volume = 14 | issue = 7 | pages = 12 | month = | year = 2008 | doi = | PMID = 18718196 }}</ref> | *[http://dermatology.cdlib.org/147/case_presentation/pen/2.jpg PEN (cdlib.org)].<ref name=pmid18718196>{{Cite journal | last1 = Newman | first1 = MD. | last2 = Milgraum | first2 = S. | title = Palisaded encapsulated neuroma (PEN): an often misdiagnosed neural tumor. | journal = Dermatol Online J | volume = 14 | issue = 7 | pages = 12 | month = | year = 2008 | doi = | PMID = 18718196 }}</ref> | ||
<gallery> | |||
File:Palisaded_and_Encapsulated_Neuroma_(3952635881).jpg | Palisaded and encapsulated neuroma (Ed Uthman) | |||
File:Palisaded_and_Encapsulated_Neuroma,_S-100_Immunostain_(3953412396).jpg| PEN, S-100 staining (Ed Uthman) | |||
</gallery> | |||
===IHC=== | ===IHC=== | ||