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Difference between revisions of "Graves' disease"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Graves disease -- low mag.jpg | |||
| Width = | |||
| Caption = Graves' disease. [[H&E stain]]. (WC) | |||
| Synonyms = | |||
| Micro = hypercellular appearance with patchy lymphocytes, little colloid that is scalloped, | |||
+/-nuclear clearing, +/-papillae | |||
| Subtypes = | |||
| LMDDx = [[papillary thyroid carcinoma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = "beefy-red" appearance, enlarged | |||
| Grossing = | |||
| Staging = | |||
| Site = [[thyroid gland]] | |||
| Assdx = [[papillary thyroid carcinoma]] | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = exophthalmos | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = TSH-receptor antibody - required | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Graves' disease''', also '''Graves disease''', is an autoimmune disease that leads to hyperthyroidism. | '''Graves' disease''', also '''Graves disease''', is an autoimmune disease that leads to hyperthyroidism. | ||
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Clinical: | Clinical: | ||
*TSH-receptor antibody +ve.<ref name=pmid19576193>{{Cite journal | last1 = Massart | first1 = C. | last2 = Gibassier | first2 = J. | last3 = d'Herbomez | first3 = M. | title = Clinical value of M22-based assays for TSH-receptor antibody (TRAb) in the follow-up of antithyroid drug treated Graves' disease: comparison with the second generation human TRAb assay. | journal = Clin Chim Acta | volume = 407 | issue = 1-2 | pages = 62-6 | month = Sep | year = 2009 | doi = 10.1016/j.cca.2009.06.033 | PMID = 19576193 }}</ref> | *TSH-receptor antibody +ve.<ref name=pmid19576193>{{Cite journal | last1 = Massart | first1 = C. | last2 = Gibassier | first2 = J. | last3 = d'Herbomez | first3 = M. | title = Clinical value of M22-based assays for TSH-receptor antibody (TRAb) in the follow-up of antithyroid drug treated Graves' disease: comparison with the second generation human TRAb assay. | journal = Clin Chim Acta | volume = 407 | issue = 1-2 | pages = 62-6 | month = Sep | year = 2009 | doi = 10.1016/j.cca.2009.06.033 | PMID = 19576193 }}</ref> | ||
*+/-Exophthalmos (bulging eyes). | |||
==Gross== | ==Gross== | ||