Difference between revisions of "Neuromuscular pathology"

Neuromuscular pathology (view source)

247 bytes added , 20:15, 7 December 2015

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 *Ragged red fibres = mitochondrial pathology.
 **Image: [http://moon.ouhsc.edu/kfung/jty1/NeuroTest/Q71-Ans.htm Ragged red fibres (ouhsc.edu)].
-*Rimmed vacuoles = [[inclusion body myositis]].
+*Vacuoles
+**Acid maltase positive = lysosomal vacuoles.
+**Rimmed vacuoles = [[inclusion body myositis]].
+**Freezing artifacts (clear).
 *PAS +++ = [[glycogen storage disease]].
-*Regenerative fibres = large nuclei, basophilic cytoplasm (incr. protein synthesis, incr. RNA).
+*Nemaline rods = [[nemaline myopathy]]
+**Image: [http://commons.wikimedia.org/w/index.php?title=File:Biopsy nemaline myopathy gomori.jpg]
+*Cores - central pale area along length of fibres in NADH stain = central core disease.
+**Image: [http://commons.wikimedia.org/w/index.php?title=File:Central core disease NADH stain.jpg].
 Others:
 *Target fibre - "hole in middle of myofibres" = neurogenic.
 **Images: [http://commons.wikimedia.org/w/index.php?title=File:Denervation_atrophy_-_very_high_mag.jpg Target fibres - very high mag. (WC)], [http://commons.wikimedia.org/wiki/File:Denervation_atrophy_-_sdh_-_very_high_mag.jpg Target fibres - SDH stain - very high mag. (WC)].
-*Cores - central pale area along length of fibres = myopathic. (???)
+*Regenerative fibres = large nuclei, basophilic cytoplasm (incr. protein synthesis, incr. RNA).
-**Image: [http://moon.ouhsc.edu/kfung/jty1/Composites/FNN0IE08-core-NADHb.htm Cores (ouhsc.edu)].
 ===Approach===