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*Rare forms can occasionally be confused with cancer.<ref name=pmid19861563>{{cite journal |author=Brosens LA, Montgomery EA, Bhagavan BS, Offerhaus GJ, Giardiello FM |title=Mucosal prolapse syndrome presenting as rectal polyposis |journal=J. Clin. Pathol. |volume=62 |issue=11 |pages=1034–6 |year=2009 |month=November |pmid=19861563 |pmc=2853932 |doi=10.1136/jcp.2009.067801 |url=}}</ref> | *Rare forms can occasionally be confused with cancer.<ref name=pmid19861563>{{cite journal |author=Brosens LA, Montgomery EA, Bhagavan BS, Offerhaus GJ, Giardiello FM |title=Mucosal prolapse syndrome presenting as rectal polyposis |journal=J. Clin. Pathol. |volume=62 |issue=11 |pages=1034–6 |year=2009 |month=November |pmid=19861563 |pmc=2853932 |doi=10.1136/jcp.2009.067801 |url=}}</ref> | ||
=== | ===Microscopic=== | ||
Features:<ref name=pmid3234303>{{cite journal |author=Schneider A, Fritze C, Bosseckert H, Machnik G |title=[Primary clinical, endoscopic and histologic findings in solitary rectal ulcer] |language=German |journal=Dtsch Z Verdau Stoffwechselkr |volume=48 |issue=3-4 |pages=183–9 |year=1988 |pmid=3234303 |doi= |url=}}</ref> | Features:<ref name=pmid3234303>{{cite journal |author=Schneider A, Fritze C, Bosseckert H, Machnik G |title=[Primary clinical, endoscopic and histologic findings in solitary rectal ulcer] |language=German |journal=Dtsch Z Verdau Stoffwechselkr |volume=48 |issue=3-4 |pages=183–9 |year=1988 |pmid=3234303 |doi= |url=}}</ref> | ||
*"Fibromuscular hyperplasia" - '''key feature''': | *"Fibromuscular hyperplasia" - '''key feature''': | ||
**Fibrosis, | **Fibrosis (submucosa, lamina propria). | ||
**Muscularis mucosae is "too superficial". | **Muscularis mucosae is "too superficial" (muscle in the lamina propria). | ||
*Surface ulceration + inflammation (neutrophils). | *Surface ulceration + inflammation (neutrophils). | ||
*+/-Serration of epithelium at the surface. | *+/-Serration of epithelium at the surface. | ||
* | |||
** | Notes: | ||
*'''Important''' NEGATIVE: no nuclear atypia. | |||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Rectal_prolapse_-_low_mag.jpg Rectal prolapse - low mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Rectal_prolapse_-_intermed_mag.jpg Rectal prolapse - intermed. mag. (WC)]. | |||
==Mucosal prolapse syndrome== | ==Mucosal prolapse syndrome== |
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