Difference between revisions of "Adrenal cortical adenoma"

Adrenal cortical adenoma (view source)

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 *[[Adrenal cortical hyperplasia]].
 **Hyperplasia is multifocal.<ref>IAV. 18 February 2009.</ref>
-*[[Adrenal cortical carcinoma]].
+*[[Adrenal cortical carcinoma]] - see ''Weiss criteria'' below.
+====Weiss criteria====
+The diagnosis of ''adrenal cortical carcinoma'' requires three of the following:<ref name=pmid20551521>{{cite journal |author=Jain M, Kapoor S, Mishra A, Gupta S, Agarwal A |title=Weiss criteria in large adrenocortical tumors: a validation study |journal=Indian J Pathol Microbiol |volume=53 |issue=2 |pages=222–6 |year=2010 |pmid=20551521 |doi=10.4103/0377-4929.64325 |url=}}</ref><ref name=pmid6703192>{{Cite journal  | last1 = Weiss | first1 = LM. | title = Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors. | journal = Am J Surg Pathol | volume = 8 | issue = 3 | pages = 163-9 | month = Mar | year = 1984 | doi =  | PMID = 6703192 }}</ref>
+#High nuclear grade.
+#High mitotic rate; >5/50 HPF (@ 40X obj.) - definition suffers from [[HPFitis]].
+#Atypical mitoses.
+#Cleared cytoplasm in >= 25% of tumour cells.
+#Sheeting (diffuse architecture) in >= 1/3 of tumour cells.
+#Necrosis in nests.
+#Venous invasion.
+#Adrenal sinusoid invasion; [[lymphovascular space invasion]] within the [[adrenal gland]].
+#Capsular invasion.
 ===Images===