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*Hypersensitivity pneumonitis (extrinic allergic alveolitis). | *Hypersensitivity pneumonitis (extrinic allergic alveolitis). | ||
== | ==Hypersensitivity pneumonitis== | ||
*AKA ''extrinsic allergic alveolitis'' | |||
*Exposure to stuffs... e.g. moldy hay - ''Farmer's lung'', atypical mycobacteria - ''hot tub lung''. | |||
*Upper lung predominant disease (???). | |||
===Microscopic=== | |||
Features: | |||
* Lesions have centrilobular prominence - '''important feature'''. <ref name=pmid16061708/> | |||
** Allergens enter lung through airway which has a centrilobular location. | |||
* Granulomata (not typically seen in UIP) - '''important feature'''.<ref name=pmid16061708>PMID 16061708.</ref> | |||
* Chronic interstitial inflammation consisting primarily of lymphocytes. | |||
* Interstitial fibrosis. | |||
* Air space involvement (alveolitis). | |||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Hypersensitivity_pneumonitis_intermed_mag.jpg Hypersensitivity pneumonitis - intermed. mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Hypersensitivity_pneumonitis_high_mag.jpg Hypersensitivity pneumonitis - high mag. (WC)]. | |||
==Pulmonary Langerhans cell histiocytosis== | ==Pulmonary Langerhans cell histiocytosis== | ||
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**Smoker's macrophages (brown pigmented airspace macrophages). | **Smoker's macrophages (brown pigmented airspace macrophages). | ||
**Chronic inflammatory cells (lymphocytes). | **Chronic inflammatory cells (lymphocytes). | ||
=Miscellaneous diseases= | =Miscellaneous diseases= |
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