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Difference between revisions of "Liver metastasis"
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→IHC
(→IHC) |
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*Metastases are typically negative for ''HepPar-1''. | *Metastases are typically negative for ''HepPar-1''. | ||
**HepPar-1 (hepatocytes paraffin antibody 1) - labels hepatocellular mitochondria.<ref name=pmid12502967>The diagnostic value of hepatocyte paraffin antibody 1 in differentiating hepatocellular neoplasms from nonhepatic tumors: a review. Lamps LW, Folpe AL. Adv Anat Pathol. 2003 Jan;10(1):39-43. Review. PMID 12502967.</ref> | **HepPar-1 (hepatocytes paraffin antibody 1) - labels hepatocellular mitochondria.<ref name=pmid12502967>The diagnostic value of hepatocyte paraffin antibody 1 in differentiating hepatocellular neoplasms from nonhepatic tumors: a review. Lamps LW, Folpe AL. Adv Anat Pathol. 2003 Jan;10(1):39-43. Review. PMID 12502967.</ref> | ||
A panel: | |||
*CK7, CK20, TTF-1, CDX2, CA-125.<ref name=pmid15897574>{{Cite journal | last1 = Dennis | first1 = JL. | last2 = Hvidsten | first2 = TR. | last3 = Wit | first3 = EC. | last4 = Komorowski | first4 = J. | last5 = Bell | first5 = AK. | last6 = Downie | first6 = I. | last7 = Mooney | first7 = J. | last8 = Verbeke | first8 = C. | last9 = Bellamy | first9 = C. | title = Markers of adenocarcinoma characteristic of the site of origin: development of a diagnostic algorithm. | journal = Clin Cancer Res | volume = 11 | issue = 10 | pages = 3766-72 | month = May | year = 2005 | doi = 10.1158/1078-0432.CCR-04-2236 | PMID = 15897574 }}</ref> | |||
Note: | Note: | ||
*If a primary is already established by pathology and the clinical impression is a metastasis, it isn't necessary to do IHC if the morphology of the lesion in the liver is compatible with the established primary. | *If a primary is already established by pathology and it isn't breast, and the clinical impression is a metastasis, it isn't necessary to do IHC if the morphology of the lesion in the liver is compatible with the established primary. | ||
==Sign out== | |||
<pre> | <pre> | ||
LIVER, PORTION OF SEGMENTS 2 AND 3, RESECTION: | LIVER, PORTION OF SEGMENTS 2 AND 3, RESECTION: | ||