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Difference between revisions of "Diffuse astrocytoma"
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*No necrosis, no vascular proliferations. | *No necrosis, no vascular proliferations. | ||
==IHC== | |||
*[[GFAP]]+ve. | *[[GFAP]]+ve. | ||
*[[MAP2]]+ve (especially in cell processes). | *[[MAP2]]+ve (especially in cell processes). | ||
| Line 31: | Line 31: | ||
*[[ATRX]] loss in 70%. | *[[ATRX]] loss in 70%. | ||
==Molecular== | |||
*Absence of LOH 1p/19q. | *Absence of LOH 1p/19q. | ||
*Tp53 mutations in approx. 60% (80-90% in gemistocytic, 50% in fibrillary types). | *Tp53 mutations in approx. 60% (80-90% in gemistocytic, 50% in fibrillary types). | ||
| Line 39: | Line 39: | ||
*Reactive astrocytosis. | *Reactive astrocytosis. | ||
*Demyelinisation. | *Demyelinisation. | ||
*[[Anaplastic astrocytoma]] | |||
*[[Oligoastrocytoma]] | |||
*[[Oligodendroglioma]] - esp. protoplasmatic forms. | |||
*[[SEGA]] - esp. gemistocytic forms. | |||
<gallery> | <gallery> | ||
File:Diffuse_astrocytoma_HE_stain.jpg | DIffuse astrocytoma, [[H&E]] (WC/jensflorian) | |||
File:Astrocytoma whoII HE.jpg | Astrocytoma, fibrillary type (WC/jensflorian) | File:Astrocytoma whoII HE.jpg | Astrocytoma, fibrillary type (WC/jensflorian) | ||
File:Neuropathology case II 02.jpg | Astrocytoma, protoplasmatic type (WC/jensflorian) | File:Neuropathology case II 02.jpg | Astrocytoma, protoplasmatic type (WC/jensflorian) | ||