Difference between revisions of "Duodenum"

Duodenum (view source)

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 ==Weird stuff==
 ==Microvillous inclusion disease==
-===General===
+{{Main|Microvillous inclusion disease}}
-*[[AKA]] Davidson's disease.
+This rare disease presents very shortly after birth.
-*Autosomal recessive inherited condition - due to mutation in ''MYO5B''.<ref name=pmid18724368>{{cite journal |author=Müller T, Hess MW, Schiefermeier N, ''et al.'' |title=MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity |journal=Nat. Genet. |volume=40 |issue=10 |pages=1163–5 |year=2008 |month=October |pmid=18724368 |doi=10.1038/ng.225 |url=}}</ref>
-===Microscopic===
-Features:
-*Flat mucosa; no villi.
-IHC:
-*Carcinoembryonic antigen (CEA) +ve.<ref name=Ref_Sternberg4>{{Ref Sternberg4|}}</ref>
-EM:
-*Diagnosis is dependent on electron microscopy.<ref>{{cite journal |author=Kennea N, Norbury R, Anderson G, Tekay A |title=Congenital microvillous inclusion disease presenting as antenatal bowel obstruction |journal=Ultrasound Obstet Gynecol |volume=17 |issue=2 |pages=172–4 |year=2001 |pmid=11251929 |doi=10.1046/j.1469-0705.2001.00211.x}}</ref>
-*Images: [http://www.gfmer.ch/genetic_diseases_v2/gendis_detail_list.php?cat3=1398 MID (gfmer.ch)].
-Notes:
-*Appearance similar to [[celiac sprue]]; however, usually lacks the intraepithelial lymphocytic infiltration characteristic of celiac sprue.
 ==Tufting enteropathy==