Difference between revisions of "Inflammatory skin disorders"

Jump to navigation Jump to search

Inflammatory skin disorders (view source)

Revision as of 20:12, 19 October 2015

2,043 bytes removed ,  20:12, 19 October 2015
→‎Pyoderma gangrenosum: split out
Line 438: Line 438:


==Pyoderma gangrenosum==
==Pyoderma gangrenosum==
===General===
{{Main|Pyoderma gangrenosum}}
*May be seen in [[IBD]] (UC and CD) - approximately 30% of cases.<ref name=pmid16858047/>
 
Clinical
*''[[Pathergy]]'' = minor trauma (to the skin) results in a non-healing lesion.<ref name=pmid22202507>{{Cite journal  | last1 = Wong | first1 = WW. | last2 = Machado | first2 = GR. | last3 = Hill | first3 = ME. | title = Pyoderma gangrenosum: the great pretender and a challenging diagnosis. | journal = J Cutan Med Surg | volume = 15 | issue = 6 | pages = 322-8 | month =  | year =  | doi =  | PMID = 22202507 }}</ref>
 
===Gross===
*Skin ulceration - classically on the legs.<ref name=pmid16858047>{{Cite journal  | last1 = Brooklyn | first1 = T. | last2 = Dunnill | first2 = G. | last3 = Probert | first3 = C. | title = Diagnosis and treatment of pyoderma gangrenosum. | journal = BMJ | volume = 333 | issue = 7560 | pages = 181-4 | month = Jul | year = 2006 | doi = 10.1136/bmj.333.7560.181 | PMID = 16858047 | PMC = 1513476 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513476/?tool=pubmed }}</ref>
 
===Microscopic===
Features:<ref name=pmid16858047/>
*Early: lymphocytes cells only in the dermis - often perivascular & vascular.
**+/-Fibrinoid necrosis of vessels at edge of lesion.
*Late: abscess formation ([[neutrophil]]s).
 
DDx:
*[[Vasculitis]].
*[[Sweet syndrome]].
 
====Image====
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513476/figure/fig5/ Pyoderma gangrenosum (nih.gov)].
 
===Sign out===
<pre>
A. Skin, Left Leg from Central Wound, Punch Biopsy:
- Necrotic debris with underlying granulation tissue and benign connective tissue
  with superficial vasculitis, see comment.
- NEGATIVE for skin surface.
 
B. Skin, Left Leg from Wound and Normal Skin Junction, Punch Biopsy:
- Skin with ulceration, necrotic debris, and superficial vasculitis, see comment.
- Fat necrosis and severe atherosclerosis.
 
Comment:
The findings are in keeping with pyoderma gangrenosum; however, atherosclerotic disease
and vasculitis should be considered clinically. 
 
The vasculitis is seen superficially and is likely secondary to the ulceration.
</pre>


==Necrobiotic xanthogranuloma==
==Necrobiotic xanthogranuloma==
Michael
48,830

edits

Retrieved from "https://librepathology.org/wiki/Special:MobileDiff/40681"

Navigation menu