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Difference between revisions of "In-transit metastasis"
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'''In-transit metastasis''' is a type of [[metastasis|metastatic disease]], characterized by tumour nodules | '''In-transit metastasis''' is a type of [[metastasis|metastatic disease]], characterized by tumour nodules arising from the lymphatics<ref name=pmid15115646>{{Cite journal | last1 = Fraker | first1 = DL. | title = Management of in-transit melanoma of the extremity with isolated limb perfusion. | journal = Curr Treat Options Oncol | volume = 5 | issue = 3 | pages = 173-84 | month = Jun | year = 2004 | doi = | PMID = 15115646 }}</ref> between the primary tumour and its local/regional [[lymph node]]s.<ref name=cancergov>URL: [http://www.cancer.gov/dictionary?cdrid=634128 http://www.cancer.gov/dictionary?cdrid=634128]. Accessed on: 28 March 2012.</ref> | ||
It is relatively common in [[malignant melanoma]].<ref name=pmid15115646>{{Cite journal | last1 = Fraker | first1 = DL. | title = Management of in-transit melanoma of the extremity with isolated limb perfusion. | journal = Curr Treat Options Oncol | volume = 5 | issue = 3 | pages = 173-84 | month = Jun | year = 2004 | doi = | PMID = 15115646 }}</ref> It may be seen in a number of tumours, e.g. squamous cell carinoma,<ref name=pmid25775628 >{{Cite journal | last1 = Kocatürk | first1 = E. | last2 = Ülkümen | first2 = PK. | last3 = Kızıltaç | first3 = U. | last4 = Yüksel | first4 = T. | last5 = Kunter | first5 = AS. | last6 = Erhan | first6 = SŞ. | title = In-transit metastasis from primary cutaneous squamous cell carcinoma in a nonimmunosuppressed patient. | journal = J Cutan Med Surg | volume = 19 | issue = 2 | pages = 167-70 | month = | year = | doi = 10.2310/7750.2014.14047 | PMID = 25775628 }}</ref><ref>{{Cite journal | last1 = Altunay | first1 = I. | last2 = Çerman | first2 = AA. | last3 = Sakiz | first3 = D. | last4 = Ates | first4 = B. | title = Marjolin's Ulcer Presenting with In-Transit Metastases: A Case Report and Literature Review. | journal = Ann Dermatol | volume = 27 | issue = 4 | pages = 442-5 | month = Aug | year = 2015 | doi = 10.5021/ad.2015.27.4.442 | PMID = 26273163 }}</ref> | It is relatively common in [[malignant melanoma]].<ref name=pmid15115646>{{Cite journal | last1 = Fraker | first1 = DL. | title = Management of in-transit melanoma of the extremity with isolated limb perfusion. | journal = Curr Treat Options Oncol | volume = 5 | issue = 3 | pages = 173-84 | month = Jun | year = 2004 | doi = | PMID = 15115646 }}</ref> It may be seen in a number of tumours, e.g. squamous cell carinoma,<ref name=pmid25775628 >{{Cite journal | last1 = Kocatürk | first1 = E. | last2 = Ülkümen | first2 = PK. | last3 = Kızıltaç | first3 = U. | last4 = Yüksel | first4 = T. | last5 = Kunter | first5 = AS. | last6 = Erhan | first6 = SŞ. | title = In-transit metastasis from primary cutaneous squamous cell carcinoma in a nonimmunosuppressed patient. | journal = J Cutan Med Surg | volume = 19 | issue = 2 | pages = 167-70 | month = | year = | doi = 10.2310/7750.2014.14047 | PMID = 25775628 }}</ref><ref>{{Cite journal | last1 = Altunay | first1 = I. | last2 = Çerman | first2 = AA. | last3 = Sakiz | first3 = D. | last4 = Ates | first4 = B. | title = Marjolin's Ulcer Presenting with In-Transit Metastases: A Case Report and Literature Review. | journal = Ann Dermatol | volume = 27 | issue = 4 | pages = 442-5 | month = Aug | year = 2015 | doi = 10.5021/ad.2015.27.4.442 | PMID = 26273163 }}</ref> | ||
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==Microscopic== | ==Microscopic== | ||
Definition - a separate tumour nodule that is:<ref>URL: [http://www.cancer.gov/dictionary?cdrid=634128 http://www.cancer.gov/dictionary?cdrid=634128]. Accessed on: 28 March 2012.</ref> | Definition - a separate tumour nodule that is:<ref name=cancergov>URL: [http://www.cancer.gov/dictionary?cdrid=634128 http://www.cancer.gov/dictionary?cdrid=634128]. Accessed on: 28 March 2012.</ref> | ||
#>2 cm from the primary tumour. | #>2 cm from the primary tumour. | ||
#Arises between the nearest (regional) [[lymph node]]s and the primary tumour. | #Arises between the nearest (regional) [[lymph node]]s and the primary tumour. | ||