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Difference between revisions of "Mucinous carcinoma"
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IHC can be used to suggest a primary site for a mucinous adenocarcinoma:<ref name=pmid21881489>{{Cite journal | last1 = Chu | first1 = PG. | last2 = Chung | first2 = L. | last3 = Weiss | first3 = LM. | last4 = Lau | first4 = SK. | title = Determining the site of origin of mucinous adenocarcinoma: an immunohistochemical study of 175 cases. | journal = Am J Surg Pathol | volume = 35 | issue = 12 | pages = 1830-6 | month = Dec | year = 2011 | doi = 10.1097/PAS.0b013e3182299c25 | PMID = 21881489 }}</ref> | IHC can be used to suggest a primary site for a mucinous adenocarcinoma:<ref name=pmid21881489>{{Cite journal | last1 = Chu | first1 = PG. | last2 = Chung | first2 = L. | last3 = Weiss | first3 = LM. | last4 = Lau | first4 = SK. | title = Determining the site of origin of mucinous adenocarcinoma: an immunohistochemical study of 175 cases. | journal = Am J Surg Pathol | volume = 35 | issue = 12 | pages = 1830-6 | month = Dec | year = 2011 | doi = 10.1097/PAS.0b013e3182299c25 | PMID = 21881489 }}</ref> | ||
*Upper GI tract: CK7 +ve (38/41 cases), CDX2 -ve (4 +ve/41 cases). | *Upper GI tract: CK7 +ve (38/41 cases), CDX2 -ve (4 +ve/41 cases). | ||
*Lower GI tract: CDX2 +ve (42/42 cases), CK20 +ve (41/42 cases), CK7 -ve (8 +ve/42 cases) positive cases usu. in rectum/anus. | *Lower GI tract: CDX2 +ve (42/42 cases), CK20 +ve (41/42 cases), CK7 -ve (8 +ve/42 cases) positive cases usu. in rectum/anus, beta-catenin (nuclear) +ve (27/42 cases). | ||
*Breast: CK7 +ve (18/18 cases), ER +ve (16/18 cases). | *Breast: CK7 +ve (18/18 cases), ER +ve (16/18 cases). | ||
*Lung: CK7 +ve (16/16 cases). | *Lung: CK7 +ve (16/16 cases). | ||
*Gynecologic: CK7 +ve (25/27 cases). | *Gynecologic: CK7 +ve (25/27 cases). | ||
A panel: | |||
*CK7, CK20, beta-catenin, CDX2. | |||
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