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Difference between revisions of "Medulloblastoma"
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IHC + DDx
Jensflorian (talk | contribs) (→Images: images desmoplastic medulloblastoma) |
Jensflorian (talk | contribs) (IHC + DDx) |
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*Homer-Wright [[rosette]]s: | *Homer-Wright [[rosette]]s: | ||
**Rosette with a meshwork of fibers (neuropil) at the centre.<ref>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | **Rosette with a meshwork of fibers (neuropil) at the centre.<ref>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | ||
==IHC== | |||
* [[MAP2]] usu. +ve | |||
* Synaptophysin +ve (weak to strong) | |||
* NSE +ve/-ve | |||
* NF +ve/-ve | |||
* Chromogranin +ve/-ve | |||
* GFAP +ve/-ve (mostly along blood vessels) | |||
* Vimentin +ve | |||
* Nestin +ve | |||
* [[INI1]] retained (no loss) | |||
DDx: | DDx: | ||
*[[Small round cell tumours]]. | *[[Small round cell tumours]]. | ||
** [[AT/RT]] | ** [[AT/RT]] (INI1 loss) | ||
** [[PNET]] | ** CNS-[[PNET]] | ||
** ETMR (LIN28)-positive | |||
** Ewing Sarcoma family members | |||
** Small cell glioblastoma | |||
==Images== | |||
<gallery> | <gallery> | ||
Image: Cerebellar medulloblastoma (1) in adult.JPG | Medulloblastoma. (WC/KGH) | Image: Cerebellar medulloblastoma (1) in adult.JPG | Medulloblastoma. (WC/KGH) | ||
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File:Medulloblastoma nuclear moulding HE stain.jpg | Epitheloid ribboning and nuclear moulding of tumor cells. (WC/jensflorian) | File:Medulloblastoma nuclear moulding HE stain.jpg | Epitheloid ribboning and nuclear moulding of tumor cells. (WC/jensflorian) | ||
File:Medulloblastoma_geographic_necrosis.jpg | Areas of geographic necrosis. (WC/jensflorian) | File:Medulloblastoma_geographic_necrosis.jpg | Areas of geographic necrosis. (WC/jensflorian) | ||
File:Medulloblastoma_MAP2_IHC.jpg | Partial MAP2 immunoreactivity. (WC/jensflorian) | File:Medulloblastoma_MAP2_IHC.jpg | Partial [[MAP2]] immunoreactivity. (WC/jensflorian) | ||
</gallery> | </gallery> | ||
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*[http://path.upmc.edu/cases/case685.html Medulloblastoma with rhabdomyoblastic differentiation - several images (upmc.edu)]. | *[http://path.upmc.edu/cases/case685.html Medulloblastoma with rhabdomyoblastic differentiation - several images (upmc.edu)]. | ||
==Subtypes== | |||
*Classic medulloblastoma (~85% of all medulloblastomas). | *Classic medulloblastoma (~85% of all medulloblastomas). | ||
*Variants of medulloblastoma (~15% of all medulloblastomas together): | *Variants of medulloblastoma (~15% of all medulloblastomas together): | ||