Difference between revisions of "Medulloblastoma"

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318 bytes added ,  09:10, 30 September 2015
IHC + DDx
(→‎Images: images desmoplastic medulloblastoma)
(IHC + DDx)
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*Homer-Wright [[rosette]]s:
*Homer-Wright [[rosette]]s:
**Rosette with a meshwork of fibers (neuropil) at the centre.<ref>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref>
**Rosette with a meshwork of fibers (neuropil) at the centre.<ref>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref>
==IHC==
* [[MAP2]] usu. +ve
* Synaptophysin +ve (weak to strong)
* NSE +ve/-ve
* NF +ve/-ve
* Chromogranin +ve/-ve
* GFAP +ve/-ve (mostly along blood vessels)
* Vimentin +ve
* Nestin +ve
* [[INI1]] retained (no loss)


DDx:
DDx:
*[[Small round cell tumours]].
*[[Small round cell tumours]].
** [[AT/RT]]
** [[AT/RT]] (INI1 loss)
** [[PNET]]
** CNS-[[PNET]]
** ETMR (LIN28)-positive
** Ewing Sarcoma family members
** Small cell glioblastoma


===Images===
==Images==
<gallery>
<gallery>
Image: Cerebellar medulloblastoma (1) in adult.JPG | Medulloblastoma. (WC/KGH)
Image: Cerebellar medulloblastoma (1) in adult.JPG | Medulloblastoma. (WC/KGH)
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File:Medulloblastoma nuclear moulding HE stain.jpg | Epitheloid ribboning and nuclear moulding of tumor cells. (WC/jensflorian)
File:Medulloblastoma nuclear moulding HE stain.jpg | Epitheloid ribboning and nuclear moulding of tumor cells. (WC/jensflorian)
File:Medulloblastoma_geographic_necrosis.jpg | Areas of geographic necrosis. (WC/jensflorian)
File:Medulloblastoma_geographic_necrosis.jpg | Areas of geographic necrosis. (WC/jensflorian)
File:Medulloblastoma_MAP2_IHC.jpg | Partial MAP2 immunoreactivity. (WC/jensflorian)
File:Medulloblastoma_MAP2_IHC.jpg | Partial [[MAP2]] immunoreactivity. (WC/jensflorian)
</gallery>
</gallery>


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*[http://path.upmc.edu/cases/case685.html Medulloblastoma with rhabdomyoblastic differentiation - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case685.html Medulloblastoma with rhabdomyoblastic differentiation - several images (upmc.edu)].


===Subtypes===
==Subtypes==
*Classic medulloblastoma (~85% of all medulloblastomas).
*Classic medulloblastoma (~85% of all medulloblastomas).
*Variants of medulloblastoma (~15% of all medulloblastomas together):
*Variants of medulloblastoma (~15% of all medulloblastomas together):
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