Difference between revisions of "Lymphoepithelioma-like carcinoma"

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Lymphoepithelioma-like carcinoma (view source)

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'''Lymphoepithelioma-like carcinoma''', abbreviated '''LELC''', is a very rare, poorly differentiated, malignant epithelial tumour.   
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Lymphoepithelioma-like_carcinoma_-_high_mag.jpg
| Width      =
| Caption    = Lymphoepithelioma-like carcinoma. [[H&E stain]].
| Synonyms  =
| Micro      = clusters of cohesive squamoid cells with abundant dense cytoplasm, central nuclei +/- small/indistinct nucleoli, surrounded by a prominent lymphoid component
| Subtypes  = (considered a subtype of [[squamous carcinoma]])
| LMDDx      = [[squamous cell carcinoma of the skin]], [[lymphoma]] (non-Hodgkin), [[medullary carcinoma]], [[nasopharyngeal carcinoma]] (head & neck)
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[skin]] and elsewhere
| Assdx      = [[EBV]] infection (dependent on anatomical site)
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Lymphoepithelioma-like carcinoma''', abbreviated '''LELC''', is a rare, poorly differentiated, malignant epithelial tumour.   


It can be considered a subtype of [[squamous carcinoma]] ([[AKA]] squamous cell carcinoma);<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970297-2#back-bib45 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970297-2#back-bib45]. Accessed on: 26 May 2011.</ref> however, some advocate it be considered a separate entity.<ref name=pmid11147469>{{Cite journal  | last1 = Skinner | first1 = NE. | last2 = Horowitz | first2 = RI. | last3 = Majmudar | first3 = B. | title = Lymphoepithelioma-like carcinoma of the uterine cervix. | journal = South Med J | volume = 93 | issue = 10 | pages = 1024-7 | month = Oct | year = 2000 | doi =  | PMID = 11147469 }}</ref>
It can be considered a subtype of [[squamous carcinoma]] ([[AKA]] squamous cell carcinoma);<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970297-2#back-bib45 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970297-2#back-bib45]. Accessed on: 26 May 2011.</ref> however, some advocate it be considered a separate entity.<ref name=pmid11147469>{{Cite journal  | last1 = Skinner | first1 = NE. | last2 = Horowitz | first2 = RI. | last3 = Majmudar | first3 = B. | title = Lymphoepithelioma-like carcinoma of the uterine cervix. | journal = South Med J | volume = 93 | issue = 10 | pages = 1024-7 | month = Oct | year = 2000 | doi =  | PMID = 11147469 }}</ref>
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Epidemiology:
Epidemiology:
*Common in Inuit and some Asians.<ref name=pathcon_lymph>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970335-7 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970335-7]. Accessed on: 11 May 2011.</ref>
*Common in Inuit and some Asians.<ref name=pathcon_lymph>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970335-7 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970335-7]. Accessed on: 11 May 2011.</ref>


Etiology:
Etiology:
*Associated with [[EBV]],<ref name=pmid17347662/> in most anatomical sites (nasopharynx, stomach, lung, thymus, salivary gland).
*Associated with [[EBV]],<ref name=pmid17347662/> in most anatomical sites (nasopharynx, [[stomach]], lung, thymus, salivary gland).
**Exceptions:  
**Exceptions:  
***Skin and [[uterine cervix]].<ref name=pmid7726142>{{Cite journal  | last1 = Lespagnard | first1 = L. | last2 = Cochaux | first2 = P. | last3 = Larsimont | first3 = D. | last4 = Degeyter | first4 = M. | last5 = Velu | first5 = T. | last6 = Heimann | first6 = R. | title = Absence of Epstein-Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction. | journal = Am J Clin Pathol | volume = 103 | issue = 4 | pages = 449-52 | month = Apr | year = 1995 | doi =  | PMID = 7726142 }}</ref>
***Skin and [[uterine cervix]].<ref name=pmid7726142>{{Cite journal  | last1 = Lespagnard | first1 = L. | last2 = Cochaux | first2 = P. | last3 = Larsimont | first3 = D. | last4 = Degeyter | first4 = M. | last5 = Velu | first5 = T. | last6 = Heimann | first6 = R. | title = Absence of Epstein-Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction. | journal = Am J Clin Pathol | volume = 103 | issue = 4 | pages = 449-52 | month = Apr | year = 1995 | doi =  | PMID = 7726142 }}</ref>
****The exception to the exception: there is a case report of EBV in LELC of the skin.<ref name=pmid20227583>{{Cite journal  | last1 = Aoki | first1 = R. | last2 = Mitsui | first2 = H. | last3 = Harada | first3 = K. | last4 = Kawamura | first4 = T. | last5 = Shibagaki | first5 = N. | last6 = Tsukamoto | first6 = K. | last7 = Murata | first7 = S. | last8 = Shimada | first8 = S. | title = A case of lymphoepithelioma-like carcinoma of the skin associated with Epstein-Barr virus infection. | journal = J Am Acad Dermatol | volume = 62 | issue = 4 | pages = 681-4 | month = Apr | year = 2010 | doi = 10.1016/j.jaad.2008.07.024 | PMID = 20227583 }}</ref>
****The exception to the exception: there is a case report of EBV in LELC of the skin.<ref name=pmid20227583>{{Cite journal  | last1 = Aoki | first1 = R. | last2 = Mitsui | first2 = H. | last3 = Harada | first3 = K. | last4 = Kawamura | first4 = T. | last5 = Shibagaki | first5 = N. | last6 = Tsukamoto | first6 = K. | last7 = Murata | first7 = S. | last8 = Shimada | first8 = S. | title = A case of lymphoepithelioma-like carcinoma of the skin associated with Epstein-Barr virus infection. | journal = J Am Acad Dermatol | volume = 62 | issue = 4 | pages = 681-4 | month = Apr | year = 2010 | doi = 10.1016/j.jaad.2008.07.024 | PMID = 20227583 }}</ref>
***[[Lymphoepithelioma-like carcinoma of the urinary bladder|Urinary bladder]].<ref name=pmid21383609>{{Cite journal  | last1 = Williamson | first1 = SR. | last2 = Zhang | first2 = S. | last3 = Lopez-Beltran | first3 = A. | last4 = Shah | first4 = RB. | last5 = Montironi | first5 = R. | last6 = Tan | first6 = PH. | last7 = Wang | first7 = M. | last8 = Baldridge | first8 = LA. | last9 = MacLennan | first9 = GT. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. | journal = Am J Surg Pathol | volume = 35 | issue = 4 | pages = 474-83 | month = Apr | year = 2011 | doi = 10.1097/PAS.0b013e31820f709e | PMID = 21383609 }}</ref>
***[[Lymphoepithelioma-like carcinoma of the urinary bladder|Urinary bladder]].<ref name=pmid21383609>{{Cite journal  | last1 = Williamson | first1 = SR. | last2 = Zhang | first2 = S. | last3 = Lopez-Beltran | first3 = A. | last4 = Shah | first4 = RB. | last5 = Montironi | first5 = R. | last6 = Tan | first6 = PH. | last7 = Wang | first7 = M. | last8 = Baldridge | first8 = LA. | last9 = MacLennan | first9 = GT. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. | journal = Am J Surg Pathol | volume = 35 | issue = 4 | pages = 474-83 | month = Apr | year = 2011 | doi = 10.1097/PAS.0b013e31820f709e | PMID = 21383609 }}</ref>


Notes:
Notes:
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DDx:
DDx:
*[[Squamous cell carcinoma of the skin]].
*[[Lymphoma]].
*[[Lymphoma]].
*[[Medullary carcinoma]].
*[[Medullary carcinoma]].
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