Difference between revisions of "Hemophagocytic syndrome"

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→‎Classification: more in genetic type
(→‎Classification: more in genetic type)
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==Classification==
==Classification==
Classified by etiology:<ref name=pmid20383897>{{cite journal |author=Gupta S, Weitzman S |title=Primary and secondary hemophagocytic lymphohistiocytosis: clinical features, pathogenesis and therapy |journal=Expert Rev Clin Immunol |volume=6 |issue=1 |pages=137–54 |year=2010 |month=January |pmid=20383897 |doi= |url=}}</ref>
Classified by etiology:<ref name=pmid20383897>{{cite journal |author=Gupta S, Weitzman S |title=Primary and secondary hemophagocytic lymphohistiocytosis: clinical features, pathogenesis and therapy |journal=Expert Rev Clin Immunol |volume=6 |issue=1 |pages=137–54 |year=2010 |month=January |pmid=20383897 |doi= |url=}}</ref>
#Primary, i.e. inherited.
#Primary, i.e. inherited:<ref name=pmid21152410>{{cite journal |author=Nagai K, Yamamoto K, Fujiwara H, ''et al.'' |title=Subtypes of familial hemophagocytic lymphohistiocytosis in Japan based on genetic and functional analyses of cytotoxic T lymphocytes |journal=PLoS ONE |volume=5 |issue=11 |pages=e14173 |year=2010 |pmid=21152410 |pmc=2994802 |doi=10.1371/journal.pone.0014173 |url=}}</ref>
#*Etiology: dysfunction of cytotoxic T lymphocytes with macrophage activating cytokines.
#*Autosomal recessive.
#*Two genes identified:
#**FHL1.<ref>{{OMIM|603552}}</ref>
#**FHL2.<ref>{{OMIM|603553}}</ref>
#Secondary:
#Secondary:
#*Infection, e.g. [[EBV]], [[HIV]].  
#*Infection, e.g. [[EBV]], [[HIV]].  
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