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#*Villi appear to be crowded.<ref>{{Ref PBoD|1109}}</ref> | #*Villi appear to be crowded.<ref>{{Ref PBoD|1109}}</ref> | ||
#**Normal spacing is ~1x smallest villus or larger. | #**Normal spacing is ~1x smallest villus or larger. | ||
#***In perivillous fibrin deposition - spacing usu. larger than normal. | |||
#Prominent syncytial knots. | #Prominent syncytial knots. | ||
#Thickened trophoblastic basement membrance (below [[cytotrophoblast]]s). | #Thickened trophoblastic basement membrance (below [[cytotrophoblast]]s). | ||
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===Microscopy=== | ===Microscopy=== | ||
Features: | |||
*Acellular eosinophilic material around formed villi. | *Acellular eosinophilic material around formed villi. | ||
*Obliteration of intervillous space. | |||
**Intervillous distance increased vis-a-vis normal - '''key feature'''. | |||
Notes: | |||
*Nuclei of villi are usu. preserved. | |||
*Villi may have secondary infarction, i.e. there may be [[Basics#Nuclear destruction words|nuclear destruction]] (karyolysis, karyorrhexis, pyknosis). | |||
=Fetal disease= | =Fetal disease= |
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