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Difference between revisions of "Case 81"
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===Additional tests=== | ===Additional tests=== | ||
====More history==== | ====More history==== | ||
{{hidden|More history|<center> | {{hidden|More history|<center>No personal history of cancer. Father died of rectal cancer. Healthy brother. Sister has a history of GI polyps. Patient mildly obese. Smoked when in her 20s. Cytoscopy shows a lesion on left lateral wall of the urinary bladder.</center>}} | ||
====Ask a colleague==== | ====Ask a colleague==== | ||
{{hidden|Ask a colleague|<center>It's an adenocarcinoma. Beta- | {{hidden|Ask a colleague|<center>It's an adenocarcinoma. Beta-cateninin and the history will give you the answer!</center>}} | ||
====Stains==== | ====Stains==== | ||
| Line 139: | Line 139: | ||
| fsh= | | fsh= | ||
| gastrin= | | gastrin= | ||
| gata3= '''POSITIVE''' | |||
| gcdfp= | | gcdfp= | ||
| gfap= | | gfap= | ||
| Line 216: | Line 217: | ||
| wt1= | | wt1= | ||
}} | }} | ||
====Chromosomal translocations==== | ====Chromosomal translocations==== | ||
{{Case Translocations | {{Case Translocations | ||
| Line 242: | Line 244: | ||
===Diagnosis=== | ===Diagnosis=== | ||
{{hidden|Diagnosis|<center>[[primary adenocarcinoma of the urinary bladder]]</center>}} | {{hidden|Diagnosis|<center>Compatible with [[primary adenocarcinoma of the urinary bladder|PRIMARY ADENOCARCINOMA OF THE URINARY BLADDER]]</center> | ||
<br> | |||
Comment:<br> | |||
These tumours look like colorectal adenocarcinoma. Beta-cateninin is the one stain that is useful; in primary adenocarcinoma the nucleus is negative and in colorectal cancer it stains the nucleus. | |||
In these types of cases, the history should be scrutinized for a history of [[colorectal carcinoma]] and urothelial carcinoma. A history of urothelial carcinoma raises the possibility of ''[[urothelial carcinoma]] with glandular differentiation''. It's ''not'' [[urachal adenocarcinoma]] as it isn't in the dome. | |||
}} | |||
<br> | <br> | ||
===Other cases=== | ===Other cases=== | ||