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Difference between revisions of "Lymphoepithelioma-like carcinoma of the urinary bladder"
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Lymphoepithelioma-like carcinoma of the urinary bladder (view source)
Revision as of 14:50, 4 August 2022
, 14:50, 4 August 2022no edit summary
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| Synonyms = | | Synonyms = | ||
| Micro = squamoid cells with abundant dense cytoplasm central nuclei +/- small/indistinct nucleoli, prominent lymphoid infiltrate | | Micro = squamoid cells with abundant dense cytoplasm central nuclei +/- small/indistinct nucleoli, prominent lymphoid infiltrate | ||
| Subtypes = subtype of [[urothelial carcinoma]] | | Subtypes = (subtype of [[urothelial carcinoma]]) | ||
| LMDDx = [[lymphoma]], [[urothelial carcinoma]] and inflammation, metastatic [[lymphoepithelioma-like carcinoma]] | | LMDDx = [[lymphoma]], [[urothelial carcinoma]] and inflammation, metastatic [[lymphoepithelioma-like carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = [[CK34betaE12]] +ve, p63 +ve/-ve, [[CK7]] +ve/-ve, [[CK20]] -ve, CD30 -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 25: | Line 25: | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = favourable on limited data | ||
| Other = not associated with [[EBV]] | | Other = not associated with [[EBV]] | ||
| ClinDDx = | | ClinDDx = | ||
| Line 35: | Line 35: | ||
*Rare. | *Rare. | ||
*Not associated with [[EBV]].<ref name=pmid21383609>{{Cite journal | last1 = Williamson | first1 = SR. | last2 = Zhang | first2 = S. | last3 = Lopez-Beltran | first3 = A. | last4 = Shah | first4 = RB. | last5 = Montironi | first5 = R. | last6 = Tan | first6 = PH. | last7 = Wang | first7 = M. | last8 = Baldridge | first8 = LA. | last9 = MacLennan | first9 = GT. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. | journal = Am J Surg Pathol | volume = 35 | issue = 4 | pages = 474-83 | month = Apr | year = 2011 | doi = 10.1097/PAS.0b013e31820f709e | PMID = 21383609 }}</ref> | *Not associated with [[EBV]].<ref name=pmid21383609>{{Cite journal | last1 = Williamson | first1 = SR. | last2 = Zhang | first2 = S. | last3 = Lopez-Beltran | first3 = A. | last4 = Shah | first4 = RB. | last5 = Montironi | first5 = R. | last6 = Tan | first6 = PH. | last7 = Wang | first7 = M. | last8 = Baldridge | first8 = LA. | last9 = MacLennan | first9 = GT. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. | journal = Am J Surg Pathol | volume = 35 | issue = 4 | pages = 474-83 | month = Apr | year = 2011 | doi = 10.1097/PAS.0b013e31820f709e | PMID = 21383609 }}</ref> | ||
*Good prognosis on scant data<ref>{{Cite journal | last1 = Fujino | first1 = T. | last2 = Kubota | first2 = M. | last3 = Nishiyama | first3 = R. | last4 = Kanno | first4 = T. | last5 = Okada | first5 = T. | last6 = Higashi | first6 = Y. | last7 = Yamada | first7 = H. | last8 = Okamoto | first8 = E. | title = [A case of lymphoepithelioma-like carcinoma of the bladder]. | journal = Hinyokika Kiyo | volume = 60 | issue = 10 | pages = 507-11 | month = Oct | year = 2014 | doi = | PMID = 25391783 }}</ref> - possibly poor if metastatic. | |||
==Microscopic== | ==Microscopic== | ||
| Line 41: | Line 42: | ||
**Abundant dense cytoplasm. | **Abundant dense cytoplasm. | ||
**Central nuclei +/- small/indistinct nucleoli. | **Central nuclei +/- small/indistinct nucleoli. | ||
* | *Prominent lymphoid infiltrate - '''key feature'''. | ||
*+/-[[Urothelial carcinoma in situ]]. | *+/-[[Urothelial carcinoma in situ]]. | ||
Note: | |||
*Peritumoural lymphoid aggregates are typical.<ref name=pmid19847088>{{Cite journal | last1 = Singh | first1 = NG. | last2 = Mannan | first2 = AA. | last3 = Rifaat | first3 = AA. | last4 = Kahvic | first4 = M. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case. | journal = Ann Saudi Med | volume = 29 | issue = 6 | pages = 478-81 | month = | year = | doi = 10.4103/0256-4947.57173 | PMID = 19847088 }}</ref> | |||
DDx: | DDx: | ||
| Line 58: | Line 62: | ||
</gallery> | </gallery> | ||
www: | www: | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881438/figure/F0002/ LELC of the urinary bladder - low mag. (nih.gov)].<ref name=pmid19847088>{{Cite journal | last1 = Singh | first1 = NG. | last2 = Mannan | first2 = AA. | last3 = Rifaat | first3 = AA. | last4 = Kahvic | first4 = M. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case. | journal = Ann Saudi Med | volume = 29 | issue = 6 | pages = 478-81 | month = | year = | doi = 10.4103/0256-4947.57173 | PMID = 19847088 }} | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881438/figure/F0002/ LELC of the urinary bladder - low mag. (nih.gov)].<ref name=pmid19847088>{{Cite journal | last1 = Singh | first1 = NG. | last2 = Mannan | first2 = AA. | last3 = Rifaat | first3 = AA. | last4 = Kahvic | first4 = M. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case. | journal = Ann Saudi Med | volume = 29 | issue = 6 | pages = 478-81 | month = | year = | doi = 10.4103/0256-4947.57173 | PMID = 19847088 }}</ref> | ||
</ref> | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881438/figure/F0003/ LELC of the urinary bladder - high mag. (nih.gov)].<ref name=pmid19847088/> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881438/figure/F0003/ LELC of the urinary bladder - high mag. (nih.gov)].<ref name=pmid19847088/> | ||
==IHC== | ==IHC== | ||
Features:<ref name=pmid21383609/> | Features:<ref name=pmid21383609/> | ||
*p53 +ve/-ve. | *p53 +ve/-ve. (+ve in ~60% of cases). | ||
*CK34betaE12 +ve (+ve in ~75% of cases). | |||
*CK7 +ve/-ve (+ve in ~60% of cases). | |||
*p63 +ve/-ve (+ve in ~50% of cases). | |||
Others:<ref name=pmid21383609/> | |||
*CK20 -ve. | *CK20 -ve. | ||
*TTF-1 -ve. | *TTF-1 -ve. | ||
*CD30 -ve. | *CD30 -ve. | ||
==See also== | ==See also== | ||
*[[Urothelial carcinoma]]. | *[[Urothelial carcinoma]]. | ||
*[[Urinary bladder]]. | *[[Urinary bladder]]. | ||
*[[Lymphoepithelioma-like carcinoma]]. | |||
*[[Nasopharyngeal carcinoma]]. | |||
==References== | ==References== | ||