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Difference between revisions of "Adrenocortical carcinoma"
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In general: | In general: | ||
*Adrenocortical adenomas are small, circumscribed and have cells with largely bland nuclei and abundant foamy clear or pink cytoplasm. | |||
Adrenocortical adenomas are small, circumscribed and have cells with largely bland nuclei and abundant foamy clear or pink cytoplasm. | *Adrenocortical carcinomas are large, infiltrative, have fibrous bands and necrosis, and cells with less cytoplasm and more atypia including atypical mitotic figures. | ||
*Adrenocortical adenomas in children; however, can look really ugly. | |||
Adrenocortical carcinomas are large, infiltrative, have fibrous bands and necrosis, and cells with less cytoplasm and more atypia including atypical mitotic figures. | |||
Adrenocortical adenomas in children; however, can look really ugly. | |||
Notes: | Notes: | ||
*Tumour may contain fat.<ref name=pmid15688105>{{cite journal |author=Heye S, Woestenborghs H, Van Kerkhove F, Oyen R |title=Adrenocortical carcinoma with fat inclusion: case report |journal=Abdom Imaging |volume=30 |issue=5 |pages=641–3 |year=2005 |pmid=15688105 |doi=10.1007/s00261-004-0281-5 |url=}}</ref> | *Tumour may contain fat.<ref name=pmid15688105>{{cite journal |author=Heye S, Woestenborghs H, Van Kerkhove F, Oyen R |title=Adrenocortical carcinoma with fat inclusion: case report |journal=Abdom Imaging |volume=30 |issue=5 |pages=641–3 |year=2005 |pmid=15688105 |doi=10.1007/s00261-004-0281-5 |url=}}</ref> | ||
====DDx==== | |||
Diagnostic categories: | |||
*[[Large epithelioid tumours|Large pink polygonal cell neoplasms]]. | |||
*Retroperitonial large polygonal cell neoplasms. | |||
**[[Adrenocortical adenoma]]. | |||
**[[Pheochromocytoma]]. | |||
**[[Malignant melanoma|Metastatic melanoma]]. | |||
**[[Hepatocellular carcinoma|Metastatic hepatocellular carcinoma]]. | |||
**[[Renal cell carcinoma|Metastatic renal cell carcinoma]]. | |||
**[[Epithelioid angiomyolipoma]]. | |||
===Images=== | ===Images=== | ||
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*"Intermediate risk" 200-400 g, no mets, +/-microscopic disease outside adrenal. | *"Intermediate risk" 200-400 g, no mets, +/-microscopic disease outside adrenal. | ||
*"High risk" >400 g, or mets, or gross invasion of adjacent structures. | *"High risk" >400 g, or mets, or gross invasion of adjacent structures. | ||
==IHC== | ==IHC== | ||