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Difference between revisions of "Stomach"
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→Gastric adenocarcinoma: +images
(→See also: +link) |
(→Gastric adenocarcinoma: +images) |
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==Gastric adenocarcinoma== | ==Gastric adenocarcinoma== | ||
===General=== | ===General=== | ||
Epidemiology: | |||
*Associated with helicobacter infections. | |||
*Prognosis is often poor as it is discovered at a late stage. | |||
*Higher prevalence in countries in the far east (e.g. Japan) - thought to be environmental, e.g. diet. | |||
Treatment: | |||
*Surgical excision. | |||
**Proximal tumours may require a complete gastrectomy as the stomach is innervated from its proximal part. | |||
====Classification==== | |||
*Two different classification schemes. | *Two different classification schemes. | ||
**Lauren<ref name=pmid14320675>{{cite journal |author=LAUREN P |title=THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION |journal=Acta Pathol Microbiol Scand |volume=64 |issue= |pages=31–49 |year=1965 |pmid=14320675 |doi= |url=}}</ref> - two types: | **Lauren<ref name=pmid14320675>{{cite journal |author=LAUREN P |title=THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION |journal=Acta Pathol Microbiol Scand |volume=64 |issue= |pages=31–49 |year=1965 |pmid=14320675 |doi= |url=}}</ref> - two types: | ||
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**WHO classification - 6 subtypes for adenocarcinoma (papillary, tubular, mucinous, signet-rign, undifferentiated, adenosquamous).<ref name=Ref_PBoD823>{{Ref PBoD |823}}</ref> | **WHO classification - 6 subtypes for adenocarcinoma (papillary, tubular, mucinous, signet-rign, undifferentiated, adenosquamous).<ref name=Ref_PBoD823>{{Ref PBoD |823}}</ref> | ||
=== | ===Microscopic=== | ||
* | Features - variable, either of the two following: | ||
* | #"Typical adenocarcinoma": | ||
* | #*Gland-forming lesion that infiltrates into the lamina propria or beyond. | ||
#*Nuclear pleomorphism - common. | |||
#+/-Signet ring carcinoma. | |||
#*Scattered single cells in the lamina propria or beyond with: | |||
#**Abundant cytoplasm containing one large (mucin-filled) vacuole. | |||
#**A peripheral nucleus (displaced by the vacuole). | |||
Images: | |||
* | *[http://commons.wikimedia.org/wiki/File:Gastric_adenocarcinoma.jpg Gastric adenocarcinoma (WC)]. | ||
* | *[http://commons.wikimedia.org/wiki/File:Signet_ring_cells_5.jpg SRC - breast (WC)]. | ||
*[http://en.wikipedia.org/wiki/File:Gastric_signet_ring_cell_carcinoma_histopatholgy_%282%29_PAS_stain.jpg Gastric SRC - PAS stain (WC)]. | |||
=== | ===IHC=== | ||
CK7 +ve. | |||
CK20 -ve, occasionally +ve. | |||
=See also= | =See also= | ||