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**Second cell layer may be difficult to see (like in breast). | **Second cell layer may be difficult to see (like in breast). | ||
*Epithelium in glands is "folded" or "tufted". | *Epithelium in glands is "folded" or "tufted". | ||
**Very important - helps | **Very important - helps to differentiate from Gleason pattern 3. | ||
*Luminal epithelium often clear cytoplasm. | *Luminal epithelium often clear cytoplasm. | ||
*Single nucleus. | *Single nucleus. |
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