Difference between revisions of "Small vessel leukocytoclastic vasculitis"

Jump to navigation Jump to search
split out
(+ca.t)
(split out)
Line 1: Line 1:
#redirect [[Vasculitides#Small_vessel_leukocytoclastic_vasculitis]]
'''Small vessel leukocytoclastic vasculitis''', also '''leukocytoclastic vasculitis''' (abbreviated '''LCV'''), is an inflammatory process of the small [[blood vessel]].
 
==General==
*Most common cutaneous vasculitis.<ref name=pmid18948765>{{Cite journal  | last1 = Brinster | first1 = NK. | title = Dermatopathology for the surgical pathologist: a pattern-based approach to the diagnosis of inflammatory skin disorders (part II). | journal = Adv Anat Pathol | volume = 15 | issue = 6 | pages = 350-69 | month = Nov | year = 2008 | doi = 10.1097/PAP.0b013e31818b1ac6 | PMID = 18948765 }}</ref>
 
Clinical:
*Palpable purpura, usu. lower extremity.
 
==Microscopic==
Features:<ref name=pmid18948765/>
*Small upper dermis vessels with:
*#Neutrophils.
*#*Fragmentation of neutrophils (leukocytoclasia).
*#Vessel damage: fibrin deposition (bright pink acellular stuff).
 
Has a very broad DDx:<ref name=pmid18948765/>
#Infectious:
#*Bacterial.
#*Viral.
#*[[Fungal]].
#Vasculitic disorders:
#*ANCA mediated vasculitides:
#**[[Wegener granulomatosis]].
#**[[Churg-Strauss syndrome]].
#*[[Henoch–Schönlein purpura]].<ref name=pmid9713395>{{Cite journal  | last1 = Kraft | first1 = DM. | last2 = Mckee | first2 = D. | last3 = Scott | first3 = C. | title = Henoch-Schönlein purpura: a review. | journal = Am Fam Physician | volume = 58 | issue = 2 | pages = 405-8, 411 | month = Aug | year = 1998 | doi =  | PMID = 9713395 }}</ref>
#*Urticarial vasculitis.
#Other:
#*[[Connective tissue disease]], e.g. [[mixed connective tissue disease]], [[SLE]], [[rheumatoid arthritis]].
#*[[Cryoglobulinemia]] - may be due to [[multiple myeloma]], [[hepatitis C]]; have intravascular thrombi.
#*Paraneoplastic.
#*Drugs.
 
Image:
*[http://www.ancavasculitis.com/biopsy.php LCA (ancavasculitis.com)].
*[http://path.upmc.edu/cases/case189.html LCA of the GI tract - several images (upmc.edu)].
 
==Stains==
*PAS - look for fungus.
 
==See also==
*[[Vasculitides]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Vasculitides]]
48,830

edits

Navigation menu