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Difference between revisions of "Kidney tumours"
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→Wilms tumour: more
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==Wilms tumour== | ==Wilms tumour== | ||
===General=== | ===General=== | ||
* | *Common abdominal [[pediatric pathology|pediatric]] tumour. | ||
===Gross=== | ===Gross=== | ||
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===Microscopic=== | ===Microscopic=== | ||
Features: | Features - classically three components: | ||
#Malignant [[Small round blue cell tumours|small round blue cells]]: | |||
**Irregular nuclear membrane. | #*Size = ~ 2x RBC diameter. | ||
** | #*Nuclear pleomorphism (variation of size, shape and staining). | ||
** | #**Irregular nuclear membrane - '''important'''. | ||
#*Scant/difficult to discern cytoplasm - basophilic (light blue). | |||
#*Mitoses - common. | |||
#Stroma: | |||
#*Spindle cells: | |||
#**Elliptical nuclear membrane. | |||
#**Abundant loose cytoplasm. | |||
#Tubular structures: | |||
#*Usually clustered. | |||
#*Vaguely resemble a glomerulus. | |||
#*Usu. have a central (clear/white) space surrounded by a rim of intensely eosinophilic cytoplasm. | |||
#*Nuclei of tubular structures often elongated and palisaded. | |||
DDx: | DDx: | ||
*Metanephric adenoma. | *Metanephric adenoma. | ||
*Other small round cell tumours. | *Other small round cell tumours. | ||
Notes: | |||
*+/-Distinct nucleoli. (???) | |||
*Palisade = fence made of stakes driven into the ground.<ref>URL: [http://www.thefreedictionary.com/palisaded http://www.thefreedictionary.com/palisaded]. Accessed on: 2 February 2011.</ref> | |||
====Anaplasia==== | |||
Any of the following: | |||
#Atypical mitoses. | |||
#Hyperchromasia. | |||
#Nuclear size variation (of the tumour cells) > 3x. | |||
===IHC=== | |||
*WT-1 +ve. | |||
=See also= | =See also= | ||