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Difference between revisions of "Postradiation prostatic carcinoma"
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Postradiation prostatic carcinoma (view source)
Revision as of 05:12, 23 July 2015
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Prostatic carcinoma and radiation changes -- high mag.jpg | |||
| Width = | |||
| Caption = Prostatic carcinoma (pale glands - left/bottom of image) and radiation changes (hyperchromatic glands with nuclear atypia (upper right of image). [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = infiltrative growth, perineural invasion, blue mucin secretions, intraluminal crystalloids | |||
| Subtypes = | |||
| LMDDx = [[radiation changes]], [[pleomorphic tumours]], postradiation prostatic sarcoma, [[sarcomatoid prostatic carcinoma]] | |||
| Stains = | |||
| IHC = AMACR +ve, CK5/6 -ve, p63 -ve, PSA +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[prostate gland]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = radiation treatment, prostate carcinoma (previously diagnosed) | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = elevated PSA or increasing PSA | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = poor (?) | |||
| Other = | |||
| ClinDDx = radiation changes, infection | |||
| Tx = salvage prostatectomy | |||
}} | |||
'''Postradiation prostatic carcinoma''', also '''prostate carcinoma after radiation therapy''', is uncommon but may be challenging to diagnose.<ref name=pmid10524518>{{Cite journal | last1 = Cheng | first1 = L. | last2 = Cheville | first2 = JC. | last3 = Bostwick | first3 = DG. | title = Diagnosis of prostate cancer in needle biopsies after radiation therapy. | journal = Am J Surg Pathol | volume = 23 | issue = 10 | pages = 1173-83 | month = Oct | year = 1999 | doi = | PMID = 10524518 }}</ref> | '''Postradiation prostatic carcinoma''', also '''prostate carcinoma after radiation therapy''', is uncommon but may be challenging to diagnose.<ref name=pmid10524518>{{Cite journal | last1 = Cheng | first1 = L. | last2 = Cheville | first2 = JC. | last3 = Bostwick | first3 = DG. | title = Diagnosis of prostate cancer in needle biopsies after radiation therapy. | journal = Am J Surg Pathol | volume = 23 | issue = 10 | pages = 1173-83 | month = Oct | year = 1999 | doi = | PMID = 10524518 }}</ref> | ||
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Features:<ref name=pmid10524518/> | Features:<ref name=pmid10524518/> | ||
*Infiltrative growth (diagnostic). | *Infiltrative growth (diagnostic). | ||
*Perineural invasion (diagnostic). | *[[Perineural invasion]] (diagnostic). | ||
*Intraluminal crystalloids. | *Intraluminal crystalloids. | ||
*Blue mucin secretions. | *Blue mucin secretions. | ||