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Difference between revisions of "Penile intraepithelial neoplasia"
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Penile intraepithelial neoplasia (view source)
Revision as of 15:43, 22 July 2015
, 15:43, 22 July 2015→Microscopic: add micro descript.
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==Microscopic== | ==Microscopic== | ||
Subclassified based on the role of [[HPV]],<ref name=pmid22641959>{{Cite journal | last1 = Velazquez | first1 = EF. | last2 = Chaux | first2 = A. | last3 = Cubilla | first3 = AL. | title = Histologic classification of penile intraepithelial neoplasia. | journal = Semin Diagn Pathol | volume = 29 | issue = 2 | pages = 96-102 | month = May | year = 2012 | doi = | PMID = 22641959 }}</ref> as in [[vulvar intraepithelial neoplasia]]: | |||
*Conventional PeIN (cPeIN). | |||
*Differentiated PeIN (dPeIN). | |||
===Classic penile intraepithelial neoplasia=== | |||
Features: | |||
*Increased [[NC ratio]]. | |||
*Multinucleation. | |||
*Lack of maturation to surface - not that useful. | |||
**May have "vertical streaming" - the long axis of the cells are perpendicular to the free surface & basement membrane. | |||
*Apical mitoses. | |||
DDx: | DDx: | ||
*[[Squamous cell carcinoma of the penis]]. | *[[Squamous cell carcinoma of the penis]]. | ||
=== | ===Differentiated penile intraepithelial neoplasia=== | ||
Features: | |||
* | *Thickening of the stratum spinosum ([[acanthosis]]). | ||
* | *Elongation of rete ridges with bridging/anastomoses between rete ridges. | ||
*[[Nuclear atypia]] - esp. of the basal layer. | |||
*Nuclei in stratum corneum ([[parakeratosis]]). | |||
*+/-Atypical mitoses. | |||
DDx: | |||
*[[Squamous cell carcinoma of the penis]]. | |||
*[[Squamous hyperplasia]]. | |||
*[[Lichen sclerosus]]. | |||
===Images=== | ===Images=== | ||