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→Other: + lymphocytic cuffing
Jensflorian (talk | contribs) (→Rosettes: update) |
Jensflorian (talk | contribs) (→Other: + lymphocytic cuffing) |
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====Other==== | ====Other important histological features==== | ||
*Rosenthal fibres = worm-like or corkscrew-like (brightly) eosinophilic bodies; 10-40 micrometers. | *Rosenthal fibres = worm-like or corkscrew-like (brightly) eosinophilic bodies; 10-40 micrometers. | ||
**Key feature: variable thickness; helps separate from RBCs. | **Key feature: variable thickness; helps separate from RBCs. | ||
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Image:Rosenthal_fibers.jpg | Rosenthal fibres - smear (WC/AFIP) | Image:Rosenthal_fibers.jpg | Rosenthal fibres - smear (WC/AFIP) | ||
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*Eosinophilic granular bodies = related to Rosenthal fibres; round cytoplasmic hyaline droplets in | *Eosinophilic granular bodies = related to Rosenthal fibres; round cytoplasmic hyaline droplets in [[astrocyte]]s.<ref>{{Ref MBNP|11}}</ref> | ||
<gallery> | |||
File:Pilocytic Micro.jpg | Eosinophilic granular bodies in pilocytic astrocytoma smear (WC/AFIP) | |||
File:PXA HE x20.jpg | Eosinophilic granular body in a pleomorphic xanthoastrocytoma (WC/jensflorian) | |||
</gallery> | |||
*Pseudopalisading - picket fence-like alignment of cells; long axis of cells perpendicular to interface with other structures/cells. | *Pseudopalisading - picket fence-like alignment of cells; long axis of cells perpendicular to interface with other structures/cells. | ||
**Pseudopalisading of tumour cells (around necrotic regions) is seen in [[glioblastoma]]. | **Pseudopalisading of tumour cells (around necrotic regions) is seen in [[glioblastoma]]. | ||
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File:GBM pseudopalisading necrosis.jpg | Pseudopalisading necrosis in a glioblastoma (WC/jensflorian) | |||
</gallery> | |||
*Perivascular lymphocytic cuffing - Lymphocytes surrounding vessels. | |||
** Seen in many inflammatory conditions including MS. | |||
** Often seen in [[ganglioglioma]] and [[pleomorphic xanthoastrocytoma]]. | |||
** Less common in some gemistocytic [[astrocytoma]]. | |||
*** No association with survival. <ref>{{Cite journal | last1 = Rossi | first1 = ML. | last2 = Jones | first2 = NR. | last3 = Candy | first3 = E. | last4 = Nicoll | first4 = JA. | last5 = Compton | first5 = JS. | last6 = Hughes | first6 = JT. | last7 = Esiri | first7 = MM. | last8 = Moss | first8 = TH. | last9 = Cruz-Sanchez | first9 = FF. | title = The mononuclear cell infiltrate compared with survival in high-grade astrocytomas. | journal = Acta Neuropathol | volume = 78 | issue = 2 | pages = 189-93 | month = | year = 1989 | doi = | PMID = 2750489 }}</ref> | |||
<gallery> | |||
File:Ganglioglioma lymphocytic cuffing PAS.jpg | Lymphocytic cuffing in [[ganglioglioma]] (WC/jensflorian) | |||
</gallery> | |||
Note: | Note: | ||