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→Microscopic: images added (tbc...)
Jensflorian (talk | contribs) (→General: overview) |
Jensflorian (talk | contribs) (→Microscopic: images added (tbc...)) |
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Microscopic: | Microscopic: | ||
*Syncytial, nuclear clearing ([[pseudoinclusions]]). | *Syncytial, nuclear clearing ([[pseudoinclusions]]). | ||
*Whorls, Onion bulb formations. | |||
*Few psammoma bodies. | |||
<gallery> | |||
File:Meningioma_showing_Psammoma_body.jpg | Psammoma body (WC/Netha Hussain) | |||
File:Meningioma_cytologie.jpg | Onion bulb formation in smear (WC/jensflorian) | |||
File:Meningioma_intermed_mag.jpg | Meningioma HPS stain (WC/Nephron) | |||
</gallery> | |||
=====Fibrous meningioma===== | =====Fibrous meningioma===== | ||
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*'''Not''' collagen... but looks like it. | *'''Not''' collagen... but looks like it. | ||
**It is really laminin or fibronectin. | **It is really laminin or fibronectin. | ||
*Spindle cells in parallel bundles. | |||
*Few to none whorl formations. | |||
<gallery> | |||
File:Meningioma_fibromatous_variant.jpg | |||
</gallery> | |||
=====Transitional meningioma===== | |||
*AKA mixed. | |||
*Common. | |||
*Lobular and fasicular growth patters coexist. | |||
*Usu. a mixture of meningeothelial and fibromatous meningioma | |||
<gallery> | |||
File:Miningioma_(1)_transitional_type.jpg | Low power (WC/KGH) | |||
File:Miningioma_(2)_transitional_type.jpg | Intermed magnification (WC/KGH) | |||
</gallery> | |||
=====Psammomatous meningioma===== | =====Psammomatous meningioma===== | ||
Microscopic: | Microscopic: | ||
*[[Psammoma bodies]]. | *[[Psammoma bodies]] dominate over tumor cells. | ||
**Irregular calcifications (confluent psammoma bodies). | |||
*Usually found in spinal cord. | |||
<gallery> | |||
File:Psammomatous_meningioma.jpg | Numerous psammoma bodies (WC/jensflorian) | |||
</gallery> | |||
=====Angiomatous meningioma===== | =====Angiomatous meningioma===== | ||
*AKA vascular. | *AKA vascular. | ||
*May bleed like stink. | *May bleed like stink. | ||
*May show extensive edema. | |||
*Hyalinized vessels dominate over tumor cells. | |||
*Degenerative nuclear atypia. | |||
DDx: | |||
*Vascular malformatons | |||
*Hemangioblastoma | |||
<gallery> | |||
File:Angiomatous_meningioma_HE_x100.jpg | Angiomatous meningioma (WC/jensflorian) | |||
</gallery> | |||
=====Microcystic meningioma===== | =====Microcystic meningioma===== | ||
Microscopic: | Microscopic: | ||
*Cystic appearance. | *Cystic appearance. | ||
*Increased cytologic pleomorphism of the elongated cells. | |||
DDx: | |||
*Clear cell meningioma | |||
*Hemangioblastoma | |||
<gallery> | |||
File:Microcystic_meningeoma_HE_x100.jpg | Microcyts (WC/jensflorian) | |||
</gallery> | |||
=====Secretory meningioma===== | =====Secretory meningioma===== | ||
| Line 142: | Line 190: | ||
Microscopic:<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/Com04/Com405-1-Diss.htm http://moon.ouhsc.edu/kfung/jty1/Com04/Com405-1-Diss.htm]. Accessed on: 12 October 2011.</ref> | Microscopic:<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/Com04/Com405-1-Diss.htm http://moon.ouhsc.edu/kfung/jty1/Com04/Com405-1-Diss.htm]. Accessed on: 12 October 2011.</ref> | ||
*Eosinophilic intracytoplasmic inclusions that are CEA +ve and PAS +ve. | *Eosinophilic intracytoplasmic inclusions that are CEA +ve and PAS +ve. | ||
Molecular: | |||
* Combined KLF4 K409Q and TRAF7 mutations.<ref>{{Cite journal | last1 = Reuss | first1 = DE. | last2 = Piro | first2 = RM. | last3 = Jones | first3 = DT. | last4 = Simon | first4 = M. | last5 = Ketter | first5 = R. | last6 = Kool | first6 = M. | last7 = Becker | first7 = A. | last8 = Sahm | first8 = F. | last9 = Pusch | first9 = S. | title = Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations. | journal = Acta Neuropathol | volume = 125 | issue = 3 | pages = 351-8 | month = Mar | year = 2013 | doi = 10.1007/s00401-013-1093-x | PMID = 23404370 }}</ref> | |||
DDx: | DDx: | ||
*Metastatic [[mucinous adenocarcinoma]]. | *Metastatic [[mucinous adenocarcinoma]]. | ||
*Pituitary adenoma | |||
<gallery> | |||
File:Secretory_meningioma_HE_x200.jpg | Secretory granules (WC/jensflorian) | |||
</gallery> | |||
Images: | Images: | ||