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Nested urothelial cell carcinoma (view source)
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'''Nested urothelial cell carcinoma''', also '''nested urothelial carcinoma''', is an aggressive subtype of [[urothelial carcinoma]] that has a bland morphology but an aggressive behaviour. | |||
It is also known as '''nested variant urothelial cell carcinoma'''. | |||
==General== | |||
*Aggressive behaviour despite bland histomorphology.<ref name=pmid14681330>{{Cite journal | last1 = Lin | first1 = O. | last2 = Cardillo | first2 = M. | last3 = Dalbagni | first3 = G. | last4 = Linkov | first4 = I. | last5 = Hutchinson | first5 = B. | last6 = Reuter | first6 = VE. | title = Nested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 12 cases. | journal = Mod Pathol | volume = 16 | issue = 12 | pages = 1289-98 | month = Dec | year = 2003 | doi = 10.1097/01.MP.0000094091.04541.FC | PMID = 14681330 }}</ref> | |||
==Microscopic== | |||
Features:<ref name=pmid2712189>{{Cite journal | last1 = Talbert | first1 = ML. | last2 = Young | first2 = RH. | title = Carcinomas of the urinary bladder with deceptively benign-appearing foci. A report of three cases. | journal = Am J Surg Pathol | volume = 13 | issue = 5 | pages = 374-81 | month = May | year = 1989 | doi = | PMID = 2712189 }}</ref> | |||
*High density of well-circumscribed nests. | |||
*Mild-to-moderate nuclear atypia. | |||
*+/-Foci of unequivocal conventional urothelial carcinoma. | |||
**Focally solid or gland fusion. | |||
**Moderate-to-severe nuclear atypia +/- abundant mitoses. | |||
*+/-Extension into the muscularis propria. | |||
DDx: | |||
*[[von Brunn nests]].<ref name=pmid21836490>{{Cite journal | last1 = Cox | first1 = R. | last2 = Epstein | first2 = JI. | title = Large nested variant of urothelial carcinoma: 23 cases mimicking von Brunn nests and inverted growth pattern of noninvasive papillary urothelial carcinoma. | journal = Am J Surg Pathol | volume = 35 | issue = 9 | pages = 1337-42 | month = Sep | year = 2011 | doi = 10.1097/PAS.0b013e318222a653 | PMID = 21836490 }}</ref> | |||
*[[Low grade papillary urothelial carcinoma]] with lamina propria invasion. | |||
==IHC== | |||
*MIB-1 typically >15%.<ref name=pmid14681330/> | |||
==See also== | |||
*[[Urothelial carcinoma]]. | |||
*[[Urothelium]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | |||
[[Category:Urothelium]] | |||