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Difference between revisions of "Renal hybrid oncocytic/chromophobe tumour"
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Renal hybrid oncocytic/chromophobe tumour (view source)
Revision as of 10:28, 15 June 2015
, 10:28, 15 June 2015no edit summary
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==General== | ==General== | ||
*Rare. | *Rare. | ||
*Molecular heterogeneous group<ref name=pmid23740406/> - may represent several different entities. | |||
May be seen in several contexts:<ref name=pmid23740406/> | May be seen in several contexts:<ref name=pmid23740406/> | ||
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*[[Birt–Hogg–Dubé syndrome]]. | *[[Birt–Hogg–Dubé syndrome]]. | ||
*Renal oncocytosis. | *Renal oncocytosis. | ||
==Microscopic== | |||
Three morphologic patterns as per Hes ''et al.'':<ref name=pmid23740406/> | |||
# [[Renal oncocytoma]] and [[chromophobe renal cell carcinoma]] [[collision tumour]]. | |||
#* Different fields viewed in isolation would be compatible with the different diagnoses. Tumour component do not intermingle. | |||
# Renal oncocytoma with scattered chromophobe cells. | |||
# Large eosinophilic cell with intracytoplasmic vacuoles. | |||
DDx: | |||
*[[Renal oncocytoma]] - may have limited chromophobe-like areas (<=5% of tumour).<ref name=pmid21166703>{{Cite journal | last1 = Trpkov | first1 = K. | last2 = Yilmaz | first2 = A. | last3 = Uzer | first3 = D. | last4 = Dishongh | first4 = KM. | last5 = Quick | first5 = CM. | last6 = Bismar | first6 = TA. | last7 = Gokden | first7 = N. | title = Renal oncocytoma revisited: a clinicopathological study of 109 cases with emphasis on problematic diagnostic features. | journal = Histopathology | volume = 57 | issue = 6 | pages = 893-906 | month = Dec | year = 2010 | doi = 10.1111/j.1365-2559.2010.03726.x | PMID = 21166703 }}</ref> | |||
*[[Chromophobe renal cell carcinoma]], eosinophilic variant. | |||
*Other [[renal tumours with eosinophilic cytoplasm]]. | |||
==IHC== | |||
Features:<ref name=pmid23740406/> | |||
*CD117 +ve (practically definitional). | |||
*CK7 +ve (usually). | |||
==See also== | ==See also== | ||